Exploration of Indolo [3, 2c] isoquinoline derived triazoles as potential antimicrobial and DNA cleavage agents: synthesis, DFT calculations, and molecular modeling …

SM Basavarajaiah, J Badiger, NG Yernale, N Gupta… - Bioorganic …, 2023 - Elsevier
Indole and its derivatives are well-known assorted motif in drug design and development.
We here in reporting synthesis of new 9-chloro-1-(4-substituted phenyl)-12H-indolo [2, 3 …

Structurally diverse diketopiperazine alkaloids from the marine-derived fungus Aspergillus versicolor SCSIO 41016

X Luo, C Chen, H Tao, X Lin, B Yang… - Organic Chemistry …, 2019 - pubs.rsc.org
Ten new diketopiperazine alkaloids (DAs, 1–10) along with two known congeners (11–12)
were characterized from the marine sponge-derived fungus Aspergillus versicolor SCSIO …

[HTML][HTML] Design and synthesis of novel 5-((3-(Trifluoromethyl) piperidin-1-yl) sulfonyl) indoline-2, 3-dione derivatives as promising Antiviral agents: in vitro, in silico …

RR Ezz Eldin, MA Saleh, SA Alwarsh, A Rushdi… - Pharmaceuticals, 2023 - mdpi.com
Herein, a series of new isatin derivatives was designed and synthesized (1–9) as broad-
spectrum antiviral agents. Consequently, the antiviral activities of the synthesized …

[HTML][HTML] Indole-Acrylonitrile Derivatives as Potential Antitumor and Antimicrobial Agents—Synthesis, In Vitro and In Silico Studies

A Kornicka, K Gzella, K Garbacz, M Jarosiewicz… - Pharmaceuticals, 2023 - mdpi.com
A series of 2-(1 H-indol-2-yl)-3-acrylonitrile derivatives, 2a–x, 3, 4a–b, 5a–d, 6a–b, and 7,
were synthesized as potential antitumor and antimicrobial agents. The structures of the …

[HTML][HTML] Synthesis, spectroscopic characterization, antibacterial activity, and computational studies of novel pyridazinone derivatives

S Daoui, Ş Direkel, MM Ibrahim, B Tüzün, T Chelfi… - Molecules, 2023 - mdpi.com
In this work, a novel series of pyridazinone derivatives (3–17) were synthesized and
characterized by NMR (1H and 13C), FT-IR spectroscopies, and ESI-MS methods. All …

[HTML][HTML] Cytotoxic and antimicrobial indole alkaloids from an endophytic fungus Chaetomium sp. SYP-F7950 of Panax notoginseng

F Peng, SY Hou, TY Zhang, YY Wu, MY Zhang… - RSC …, 2019 - pubs.rsc.org
Two new compounds chetoseminudin F (1) and G (2) together with eleven known
compounds were isolated from the solid fermentation products of the endophytic fungus …

[HTML][HTML] Identification of novel antifungal agents: antimicrobial evaluation, SAR, ADME–Tox and molecular docking studies of a series of imidazole derivatives

B Bouchal, F Abrigach, A Takfaoui, M Elidrissi Errahhali… - BMC chemistry, 2019 - Springer
Thirty-four imidazole-based compounds synthesized by one-pot catalytic method were
evaluated for their antifungal and antibacterial activities against several fungal and bacterial …

Design and Synthesis of Imine Derivatives: DFT, Molecular Docking and Antimicrobial Analysis

B Kumari, K Ahmad - ChemistrySelect, 2023 - Wiley Online Library
Fifteen imine compounds were synthesized from the condensation of (Z)‐3‐(4‐
bromophenyl)‐3‐(5‐methyl‐2‐thioxo‐1, 3, 4‐thiadiazol‐3 (2H)‐yl) acrylaldehyde and …

The effects of tryptophan and hydrophobicity on the structure and bioactivity of novel indolicidin derivatives with promising pharmaceutical potential

AP Podorieszach… - Organic & biomolecular …, 2010 - pubs.rsc.org
In the current study, indolicidin, a known antimicrobial originally isolated from bovine
neutrophils, was modified with respect to hydrophobicity and tryptophan content to maximize …

Synthesis, antimicrobial, DFT, and in silico pharmacokinetic profiling of nitroaldol quinoline derivatives: A comprehensive exploration for designing potential oral …

F Guenfoud, O Khaoua, Z Cherak, L Loucif… - Journal of Molecular …, 2024 - Elsevier
This study presents a thorough exploration of the synthesis, biological activities, and
molecular properties of a novel series of β-nitroaldol quinoline derivatives (4a-4i). Structural …