Microsatellite instability (MSI) is a hypermutable phenotype caused by the loss of DNA
mismatch repair activity. MSI is detected in about 15% of all colorectal cancers; 3% are of …

Purpose: The genomic instability in colon cancer can be divided into at least two major
types, microsatellite instability (MSI) or chromosomal instability (CIN). Although initially felt to …

Purpose Although the incidence of microsatellite instability (MSI) accounts for 10-15% of
cases of colorectal cancer, its clinical application for all colorectal cancers has widened. We …

Purpose: Many studies have evaluated the role of high levels of microsatellite instability
(MSI) as a prognostic marker and predictor of the response to chemotherapy in colorectal …

BACKGROUND AND AIMS In this study, we prospectively examined the clinical significance
of the microsatellite instability (MSI) phenotype in sporadic colorectal cancer, and …

Although microsatellite instability (MSI) has been shown to be present in 15% of sporadic
colorectal carcinomas, the genetic events underlying the development of these tumors have …

Hereditary non‐polyposis colorectal cancer (HNPCC) is a dominantly inherited syndrome
linked to DNA‐mismatch‐repair (MMR) gene defects, which also account for microsatellite …

Abstract The Hong Kong Chinese population has an unusually high incidence of colorectal
cancer in the young, suggestive of hereditary susceptibility. To search for a genetic basis for …

The microsatellite instability (MSI) mutational pathway is critical to carcinogenesis in a small
but significant proportion of colorectal cancers. While MSI is identified in most cancers in …

A subset of hereditary and sporadic colorectal carcinomas is defined by microsatellite
instability (MSI), but the spectra of gene mutations have not been characterized extensively …