Notch signaling is a major intercellular coordination mechanism highly conserved
throughout evolution. In vertebrates, Notch signaling is physiologically involved in embryo …

Rationale: Deregulated vascular smooth muscle cell (VSMC) proliferation contributes to
multiple vascular pathologies, and Notch signaling regulates VSMC phenotype. Objective …

Notch signaling has been shown recently to regulate vascular cell fate in adult cells. By
applying a uniform equibiaxial cyclic strain to vascular smooth muscle cells (SMCs), we …

Notch3 is one of the four Notch receptors identified in mammal and expressed mainly in the
arterial smooth muscle cells of human adult. Signalling via Notch3 is thought to be important …

The formation of blood vessels within the vascular system entails a variety of cellular
processes, including proliferation, migration and differentiation. In many cases, these …

Cell–cell interactions define a quintessential aspect of multicellular development. Metazoan
morphogenesis depends on a handful of fundamental, conserved cellular interaction …

The Notch signalling pathway is a key regulator of developmental and tumour angiogenesis.
Inhibition of Delta-like 4 (Dll4)-mediated Notch signalling results in hyper-sprouting …

Notch family proteins play a key role in a variety of developmental processes by controlling
cell fate decisions and operating in a great number of biological processes in several organ …

Signals through the Notch receptors are used throughout development to control cellular
fate choices. Our intention here is to provide an overview of the involvement of Notch …

The evolutionarily conserved developmental pathway driven by Notch receptors and ligands
has acquired multiple post-natal homeostatic functions in vertebrates. Potential roles in …