Background—Notch1 regulates binary cell fate determination and is critical for angiogenesis
and cardiovascular development. However, the pathophysiological role of Notch1 in the …

Angiogenesis, or the formation of new blood vessels from pre-existing ones, is essential to
establish the vascular circuit during embryonic development. During angiogenic sprouting …

The evolutionarily conserved NOTCH signaling displays pleotropic functions in almost every
organ system with a simple signaling axis. Different from many other signaling pathways that …

The discovery that Notch, a key regulator of cell fate determination, is functional in the
vasculature has greatly improved our understanding of differentiation and specialization of …

Notch signaling has been implicated in a wide variety of processes from cell-fate decisions,
tissue patterning and morphogenesis to human diseases and cancer. A model for Notch …

The Notch family of receptors and downstream effectors plays a critical role in cell fate
determination during vascular ontogeny. Moreover, the human cerebralautosomal dominant …

The Notch pathway is crucial in the regulation of stem cells biology. Notch-mediated
signalling controls several aspects of tissue homeostasis in both embryonic and adult …

The highly conserved Notch signaling pathway plays pleiotropic roles during embryonic
development and is important for the regulation of selfrenewing tissues. The physiological …

The Notch family of cell‐surface receptors has been proposed to regulate cell‐fate decisions
by modulating the ability of each cell to respond to environmental cues. In vertebrates, gain …

Vascular smooth muscle cell (SMC) fate decisions (cell growth, migration, and apoptosis)
are fundamental features in the pathogenesis of vascular disease. We investigated the role …