Cerebral ischemia is caused by arterial occlusion due to a thrombus or an embolus. Such
occlusion induces multiple and concomitant pathophysiological processes that involve …

The immune response to stroke is an exciting target for future stroke therapies. Stroke is a
leading cause of morbidity and mortality worldwide, and clot removal (mechanical or …

Stroke disrupts the homeostatic balance within the brain and is associated with a significant
accumulation of necrotic cellular debris, fluid, and peripheral immune cells in the central …

Increasing evidence shows that the central nervous system and the immune system interact
in complex ways, and better insight into these interactions may be relevant to the treatment …

Stroke is one of the leading causes of death and disability worldwide. The long‐standing
dogma that stroke is exclusively a vascular disease has been questioned by extensive …

Immunity and inflammation are key elements of the pathobiology of stroke, a devastating
illness second only to cardiac ischemia as a cause of death worldwide. The immune system …

Ischemic stroke is the most frequent cause of persistent neurologic disability in modern
Western societies. Albeit it is still not clear whether inflammation is merely an …

Stroke is a major cause of morbidity and mortality worldwide. Despite the intensive search
for new therapies, hundreds of agents targeting various pathophysiological mechanisms …

Stroke, the third leading cause of death and disability worldwide, is undergoing a change in
perspective with the emergence of new ideas on neurodegeneration. The concept that …

Reperfusion of ischemic brain can reduce injury and improve outcome, but secondary injury
due to inflammatory mechanisms limits the efficacy and time window of such treatments for …