Immune cell infiltration into the brain after ischemic stroke in humans compared to mice and rats: a systematic review and meta-analysis

C Beuker, JK Strecker, R Rawal… - Translational stroke …, 2021 - Springer
Although several studies have suggested that anti-inflammatory strategies reduce
secondary infarct growth in animal stroke models, clinical studies have not yet demonstrated …

T cell response in ischemic stroke: from mechanisms to translational insights

D Zhang, J Ren, Y Luo, Q He, R Zhao, J Chang… - Frontiers in …, 2021 - frontiersin.org
Ischemic stroke, caused by a sudden disruption of blood flow to the brain, is a leading cause
of death and exerts a heavy burden on both patients and public health systems. Currently …

Suppression of inflammation in ischemic and hemorrhagic stroke: therapeutic options

TJ Kleinig, R Vink - Current opinion in neurology, 2009 - journals.lww.com
Inhibiting inflammation following both ischemic and hemorrhagic stroke remains a promising
approach. More sophisticated therapies, with pleiotropic beneficial effects, and more …

Immune mechanisms of stroke

T Magnus, H Wiendl, C Kleinschnitz - Current opinion in …, 2012 - journals.lww.com
Immune mechanisms of stroke : Current Opinion in Neurology Immune mechanisms of
stroke : Current Opinion in Neurology Log in or Register Subscribe to journalSubscribe Get …

Cellular and molecular mechanisms of sterile inflammation in ischaemic stroke

K Nakamura, T Shichita - The journal of biochemistry, 2019 - academic.oup.com
Cerebral inflammation is a promising therapeutic target for ischaemic stroke. After ischaemic
stroke, inflammatogenic self-molecules, which originate from damaged brain tissue due to …

Molecular and cellular immune responses to ischemic brain injury

HA Seifert, KR Pennypacker - Translational stroke research, 2014 - Springer
Despite extensive research into stroke pathology, there have not been any major recent
advancements in stroke therapeutics. Animal models of cerebral ischemia and clinical data …

Inflammation following stroke

MN Perera, HK Ma, S Arakawa, DW Howells… - Journal of Clinical …, 2006 - Elsevier
Stroke is one of the leading causes of mortality and morbidity. The stroke process triggers an
inflammatory reaction that may last up to several months. Suppression of inflammation using …

Effect of experimental stroke on peripheral immunity: CNS ischemia induces profound immunosuppression

H Offner, AA Vandenbark, PD Hurn - Neuroscience, 2009 - Elsevier
The profound damage to the CNS caused by ischemic lesions has been well documented.
Yet, relatively little is known about the contribution to and effects on the immune system …

Role of inflammation and its mediators in acute ischemic stroke

R Jin, L Liu, S Zhang, A Nanda, G Li - Journal of cardiovascular …, 2013 - Springer
Inflammation plays an important role in the pathogenesis of ischemic stroke and other forms
of ischemic brain injury. Increasing evidence suggests that inflammatory response is a …

[HTML][HTML] Immune pathway activation in neurons triggers neural damage after stroke

D Wu, J Liu, J Liu, W Ge, S Wu, C Zeng, J Liang, KJ Liu… - Cell Reports, 2023 - cell.com
Ischemic brain injury is a severe medical condition with high incidences in elderly people
without effective treatment for the resulting neural damages. Using a unilateral mouse stroke …