ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors
Induced pluripotent stem cells (iPSCs), which are used to produce transplantable tissues,
may particularly benefit older patients, who are more likely to suffer from degenerative …
may particularly benefit older patients, who are more likely to suffer from degenerative …
[HTML][HTML] Sirt6 promotes DNA end joining in iPSCs derived from old mice
W Chen, N Liu, H Zhang, H Zhang, J Qiao, W Jia, S Zhu… - Cell reports, 2017 - cell.com
Induced pluripotent stem cells (iPSCs) have great potential for treating age-related diseases,
but the genome integrity of iPSCs is critically important. Here, we demonstrate that non …
but the genome integrity of iPSCs is critically important. Here, we demonstrate that non …
[HTML][HTML] Zscan4 promotes genomic stability during reprogramming and dramatically improves the quality of iPS cells as demonstrated by tetraploid complementation
Induced pluripotent stem (iPS) cells generated using Yamanaka factors have great potential
for use in autologous cell therapy. However, genomic abnormalities exist in human iPS cells …
for use in autologous cell therapy. However, genomic abnormalities exist in human iPS cells …
Concise review: induced pluripotency by defined factors: prey of oxidative stress
S Qi, Z Fang, D Wang, P Menendez, K Yao, J Ji - Stem Cells, 2015 - academic.oup.com
Reprogramming somatic cells to pluripotency (induced pluripotent stem cells, iPSCs) via
forced expression of defined factors has become one of the most fascinating areas in …
forced expression of defined factors has become one of the most fascinating areas in …
[HTML][HTML] Antioxidant supplementation reduces genomic aberrations in human induced pluripotent stem cells
J Ji, V Sharma, S Qi, ME Guarch, P Zhao, Z Luo, W Fan… - Stem cell reports, 2014 - cell.com
Somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) using
oncogenic transcription factors. However, this method leads to genetic aberrations in iPSCs …
oncogenic transcription factors. However, this method leads to genetic aberrations in iPSCs …
[HTML][HTML] Mitochondrial-associated cell death mechanisms are reset to an embryonic-like state in aged donor-derived iPS cells harboring chromosomal aberrations
A Prigione, AM Hossini, B Lichtner, A Serin, B Fauler… - PloS one, 2011 - journals.plos.org
Somatic cells reprogrammed into induced pluripotent stem cells (iPSCs) acquire features of
human embryonic stem cells (hESCs) and thus represent a promising source for cellular …
human embryonic stem cells (hESCs) and thus represent a promising source for cellular …
[HTML][HTML] DNA damage response and cell cycle regulation in pluripotent stem cells
ACH Chen, Q Peng, SW Fong, KC Lee, WSB Yeung… - Genes, 2021 - mdpi.com
Pluripotent stem cells (PSCs) hold great promise in cell-based therapy because of their
pluripotent property and the ability to proliferate indefinitely. Embryonic stem cells (ESCs) …
pluripotent property and the ability to proliferate indefinitely. Embryonic stem cells (ESCs) …
High‐Fidelity Reprogrammed Human IPSCs Have a High Efficacy of DNA Repair and Resemble hESCs in Their MYC Transcriptional Signature
PK Nagaria, C Robert, TS Park, JS Huo… - Stem cells …, 2016 - Wiley Online Library
Human induced pluripotent stem cells (hiPSCs) are reprogrammed from adult or progenitor
somatic cells and must make substantial adaptations to ensure genomic stability in order to …
somatic cells and must make substantial adaptations to ensure genomic stability in order to …
[HTML][HTML] High glutathione and glutathione peroxidase-2 levels mediate cell-type-specific DNA damage protection in human induced pluripotent stem cells
B Dannenmann, S Lehle, DG Hildebrand, A Kübler… - Stem cell reports, 2015 - cell.com
Pluripotent stem cells must strictly maintain genomic integrity to prevent transmission of
mutations. In human induced pluripotent stem cells (iPSCs), we found that genome …
mutations. In human induced pluripotent stem cells (iPSCs), we found that genome …
[HTML][HTML] Biological significance of the suppression of oxidative phosphorylation in induced pluripotent stem cells
We discovered that induced pluripotent stem cell (iPSC) clones generated from aged tissue
donors (A-iPSCs) fail to suppress oxidative phosphorylation. Compared to embryonic stem …
donors (A-iPSCs) fail to suppress oxidative phosphorylation. Compared to embryonic stem …