RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation

Y Yue, J Liu, C He - Genes & development, 2015 - genesdev.cshlp.org
N 6-methyladenosine (m6A) is the most prevalent and internal modification that occurs in the
messenger RNAs (mRNA) of most eukaryotes, although its functional relevance remained a …

The biogenesis and precise control of RNA m6A methylation

H Huang, H Weng, J Chen - Trends in Genetics, 2020 - cell.com
N 6-Methyladenosine (m 6 A) is the most prevalent internal RNA modification in mRNA, and
has been found to be highly conserved and hard-coded in mammals and other eukaryotic …

N6-methyladenosine-mediated gene regulation and therapeutic implications

Y Liu, D Yang, T Liu, J Chen, J Yu, P Yi - Trends in molecular medicine, 2023 - cell.com
Abstract N6-methyladenosine (m 6 A) RNA methylation is the most abundant form of mRNA
modification in eukaryotes and is at the front line of biological and biomedical research. This …

N6‐methyladenosine modification in mRNA: machinery, function and implications for health and diseases

A Maity, B Das - The FEBS journal, 2016 - Wiley Online Library
N6‐methyladenosine (m6A) modification in mRNA is extremely widespread, and functionally
modulates the eukaryotic transcriptome to influence mRNA splicing, export, localization …

The dynamic epitranscriptome: N6-methyladenosine and gene expression control

KD Meyer, SR Jaffrey - Nature reviews Molecular cell biology, 2014 - nature.com
Abstract N 6-methyladenosine (m6A) is a modified base that has long been known to be
present in non-coding RNAs, ribosomal RNA, polyadenylated RNA and at least one …

[HTML][HTML] Function and evolution of RNA N6-methyladenosine modification

ZM Zhu, FC Huo, DS Pei - International journal of biological …, 2020 - ncbi.nlm.nih.gov
Abstract N6-methyladenosine (m 6 A) is identified as the most prevalent and abundant
internal RNA modification, especially within eukaryotic mRNAs, which has attracted much …

Role of the N6-methyladenosine RNA mark in gene regulation and its implications on development and disease

U Chandola, R Das, B Panda - Briefings in functional genomics, 2015 - academic.oup.com
Epigenetics is a field that encompasses chemical modifications of DNA and histone proteins,
both of which alter gene expression without changing the underlying nucleotide sequence …

N6-Methyl-Adenosine (m6A) in RNA: An Old Modification with A Novel Epigenetic Function

Y Niu, X Zhao, YS Wu, MM Li, XJ Wang… - Genomics, proteomics …, 2013 - academic.oup.com
Abstract N6-methyl-adenosine (m6A) is one of the most common and abundant
modifications on RNA molecules present in eukaryotes. However, the biological significance …

RNA m6A methylation across the transcriptome

E Sendinc, Y Shi - Molecular cell, 2023 - cell.com
Since the early days of foundational studies of nucleic acids, many chemical moieties have
been discovered to decorate RNA and DNA in diverse organisms. In mammalian cells, one …

Biological roles of adenine methylation in RNA

K Boulias, EL Greer - Nature Reviews Genetics, 2023 - nature.com
Abstract N 6-Methyladenosine (m6A) is one of the most abundant modifications of the
epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in …