Peptide dendrimer–doxorubicin conjugate‐based nanoparticles as an enzyme‐responsive drug delivery system for cancer therapy

C Zhang, D Pan, K Luo, W She, C Guo… - Advanced …, 2014 - Wiley Online Library
Peptide dendrimers have shown promise as an attractive platform for drug delivery. In this
study, mPEGylated peptide dendrimer–doxorubicin (dendrimer–DOX) conjugate‐based …

Amphiphilic peptide dendritic copolymer-doxorubicin nanoscale conjugate self-assembled to enzyme-responsive anti-cancer agent

N Li, N Li, Q Yi, K Luo, C Guo, D Pan, Z Gu - Biomaterials, 2014 - Elsevier
Peptide dendrimer drug conjugate based nanoparticles are recently developed as a
potential candidate for drug delivery vehicle. In this study, we prepared and characterized …

The potential of self-assembled, pH-responsive nanoparticles of mPEGylated peptide dendron–doxorubicin conjugates for cancer therapy

W She, K Luo, C Zhang, G Wang, Y Geng, L Li, B He… - Biomaterials, 2013 - Elsevier
Nanoparticles, such as dendritic polymers, are currently investigated as excellent
candidates for drug delivery vehicles. In this study, we report the preparation and …

Enzyme-responsive peptide dendrimer-gemcitabine conjugate as a controlled-release drug delivery vehicle with enhanced antitumor efficacy

C Zhang, D Pan, J Li, J Hu, A Bains, N Guys, H Zhu… - Acta biomaterialia, 2017 - Elsevier
Stimuli-responsive peptide dendrimer-drug conjugates have presented significant potential
for cancer therapy. To develop an effective nanoscale chemotherapeutic prodrug, we …

Enzyme-responsive doxorubicin release from dendrimer nanoparticles for anticancer drug delivery

SJ Lee, YI Jeong, HK Park, DH Kang… - International journal …, 2015 - Taylor & Francis
Background Since cancer cells are normally over-expressed cathepsin B, we synthesized
dendrimer-methoxy poly (ethylene glycol)(MPEG)-doxorubicin (DOX) conjugates using a …

Dendrimer–doxorubicin conjugate as enzyme-sensitive and polymeric nanoscale drug delivery vehicle for ovarian cancer therapy

C Zhang, D Pan, K Luo, N Li, C Guo, X Zheng… - Polymer Chemistry, 2014 - pubs.rsc.org
Peptide dendrimer-based nanoparticles have presented significant potential as candidates
for drug delivery system. In this study, we synthesized and characterized enzyme-responsive …

Enzyme-sensitive cytotoxic peptide–dendrimer conjugates enhance cell apoptosis and deep tumor penetration

FH Liu, CY Hou, D Zhang, WJ Zhao, Y Cong… - Biomaterials …, 2018 - pubs.rsc.org
Peptide nanodrugs have been developed as promising antitumor chemotherapeutics
because they partially overcome the drawbacks of free peptide drugs, but insufficient tumor …

DOX-loaded peptide dendritic copolymer nanoparticles for combating multidrug resistance by regulating the lysosomal pathway of apoptosis in breast cancer cells

J Wang, N Li, L Cao, C Gao, Y Zhang… - Journal of Materials …, 2020 - pubs.rsc.org
Multidrug resistance (MDR) is a common phenomenon in clinical oncology and is a major
obstacle to cancer chemotherapy. Many nanoparticle (NP)-based drug delivery systems …

Co-delivery of cisplatin and doxorubicin by covalently conjugating with polyamidoamine dendrimer for enhanced synergistic cancer therapy

XL Guo, XX Kang, YQ Wang, XJ Zhang, CJ Li, Y Liu… - Acta biomaterialia, 2019 - Elsevier
Because of the synergistic effects of drugs and minimal drug dose for cancer therapy,
combination chemotherapy is frequently used in the clinic. In this study, hyaluronic acid …

RGD peptide-modified multifunctional dendrimer platform for drug encapsulation and targeted inhibition of cancer cells

X He, CS Alves, N Oliveira, J Rodrigues, J Zhu… - Colloids and Surfaces B …, 2015 - Elsevier
Abstract Development of multifunctional nanoscale drug-delivery systems for targeted
cancer therapy still remains a great challenge. Here, we report the synthesis of cyclic …