The high prevalence of prostate cancer (PCa) in elderly men and technical advances in
early detection of localized PCa have led to continued efforts to develop new therapeutic …

Canine prostate is widely used as animal model in the preclinical evaluation of emerging
therapeutic interventions. Spontaneous benign prostatic hyperplasia (BPH) is common in …

Abstract Background Prostate cancer (PCa) models in mice and rats are limited by their size
and lack of a clearly delineated or easily accessible prostate gland. The canine PCa model …

BACKGROUND No existing animal model fully recapitulates all features of human prostate
cancer. The dog is the only large mammal, besides humans, that commonly develops …

BACKGROUND Rodent models are often suboptimal for translational research on human
prostate cancer (PCa). To better fill the gap with human, we refined the previously described …

Though relatively rare in dogs, prostate cancer (PCa) is the most common non‐cutaneous
cancer in men. Human and canine prostate glands share many functional, anatomical and …

Background Prostate diseases in the dog are generally regarded as representative for their
human counterparts. We characterized the normal canine prostate in comparison to the …

BACKGROUND Pet dogs and men share a vulnerability for the development of prostate
carcinoma. The purpose of this study was to further characterize the clinical and pathologic …

Despite substantial similarities in embryological, cellular and molecular biology features,
human and mouse prostates differ in organ morphology and tissue architecture. Thus, a …

Simple Summary The incidence of prostate cancer is rising, primarily due to its prevalence
among elderly men, and with increased life expectancy, these numbers are expected to …