Computational modeling provides a potentially powerful way to integrate structural
properties measured in vitro to physiological functions measured in vivo. Focusing on the …

Computational methods for tissue biomechanics, electrophysiology, and cellular physiology
separately provide frameworks for modeling functions of cardiac tissue. We review strategies …

We present a computational modeling and numerical simulation framework that enables the
integration of multiple physics and spatiotemporal scales in models of physiological …

Computer-based numerical simulations of the heart, also known as in silico cardiac models,
are increasingly assuming a recognized role in the context of computational medicine and …

The importance and need for an integrative mathematical modeling approach in the
biological and medical fields is currently well recognized. Such an approach is crucial in …

Personalised computer models of cardiac function, referred to as cardiac digital twins, are
envisioned to play an important role in clinical precision therapies of cardiovascular …

Models of cardiac tissue electrophysiology are an important component of the Cardiac
Physiome Project, which is an international effort to build biophysically based multi-scale …

The simulation of cardiac electrical function is an example of a successful integrative
multiscale modelling approach that is directly relevant to human disease. Today we stand at …

The key objective of this work is the design of an unconditionally stable, robust, efficient,
modular, and easily expandable finite element‐based simulation tool for cardiac …

Recent developments in cardiac simulation have rendered the heart the most highly
integrated example of a virtual organ. We are on the brink of a revolution in cardiac …