In a previous report (l), equations were derived to describe the time course of drug levels
during enzyme induction under various drug input conditions: single-dose intravenous …

Clinical pharmacology is accepted as an academic discipline in the United Staates, Sweden
and the United Kingdom, and it is developing in a number of other countries. There is …

This paper must necessarily take the form of a progress report. Many aspects of our work,
particularly with regard to human disposition and metabolism, are continuing at this time …

Definition and Implications of Dose-Dependent Kinetics in Clinical Medicine Page 1 DRUG
METABOLISM REVIEWS, 14( 61, 1103-1117 (1983) Definition and Implications of DoseDependent …

Evidence of effectiveness of a newly developed drug is obtained from an organized search
for an expected result in a selected population. In contrast, the search for risks is open …

The effects of cimetidine (single or repeated administration) on free unchanged captopril
plasma levels, pharmacokinetic parameters and plasma converting enzyme inhibitory effects …

1 The effects of the orally active angiotensin converting enzyme inhibitor, captopril, were
examined in 15 patients with mild or moderate essential hypertension. 2 Following initial …

The kinetics of captopril plasma levels and of the drug‐induced plasma converting enzyme
activity (PCEA), plasma renin activity (PRA) and diastolic blood pressure (DBP) …

It is widely accepted that pharmacologic reduction of the blood pressure of hypertensive
patients reduces the risk of at least some of the major cardiovascular complications (1–5). All …

A simple model simulating the kinetics of drug metabolism inhibition interaction is
investigated. The relative sensitivity of drug and metabolite concentration-time profiles as …