14C‐Captopril was administered as 100‐mg tablets to 12 subjects in a two‐way crossover
study in which subjects were either fasted or were given a standard meal immediately prior …

A method is described which allows the calculation of kinetic parameters of drugs from two
data points, involving a set of simple algebraic equations. This method is based on …

Three new angiotensin converting‐enzyme inhibitors were given orally to 20 men in single
doses ranging from 1.25 to 40 mg. Two of them induced comparable marked inhibition of …

The increasing number of angiotensin converting enzyme (ACE) inhibitors means that
compounds with different enzyme kinetics, pharmacokinetics, bioavailability, and …

A simple method for determination of the apparent elimination rate constant of a metabolite
(km) has been developed. This procedure requires calculation of area intervals under the …

1 WILLIAM N. CHARMAN, SUSAN A. CHARMAN, DONALD C. MONKHOUSE, STEVEN E.
FRISBEE, EARLE A. LOCKHART, STEVEN WEISMAN, GARRET A. FITZGERALD …

1. The pharmacokinetics of most ACE inhibitors have been evaluated indirectly by the
measurements of plasma ACE activity and circulating levels of angiotensin I and II. 2 …

A method is described for determining the in vivo Km and Vmax values for a drug, utilizing a
variant of the Michaelis‐Menten equation and the elimination‐rate constants of tracer doses …

A Large number of pharmacologically important compounds have been found to act as
enzyme inhibitors and a kinetic study of the inhibitory process can provide important …

When a pharmacokinetic model is fitted to blood levels of a drug, the estimates of the
pharmacokinetic parameters are likely to be subject to considerable error. These errors are …