When a pharmacokinetic model is fitted to blood levels of a drug, the estimates of the
pharmacokinetic parameters are likely to be subject to considerable error. These errors are …

The development of angiotensin converting enzyme inhibitors is often cited as a prime
example of task oriented research. The truth is far from this, and, as so often, chance played …

Application of pharmacokinetic principles to patient therapy requires prior elucidation of the
relationship between the plasma concentration of a drug and its pharmacological effects …

After administration of captopril, a decrease in mean arterial blood pressure was observed in
low sodium rats which were used as animal models of hyper-renin-active athe-ma. In normal …

The renin-angiotensin-aldosterone system is inti-mately involved in the regulation of
vascular tone, and is central to sodium homeostasis; the octapeptide angiotensin II, formed …

To apprcClate Ihe Lmportance of clinical pharo macokinctic studies In Ihe drug regulatory
process 11 is necessaT) 10 understand the role of the rcgulalory authoTitles throughout the …

With the launching of a new journal devoted to Clinical Pharmacology, it is, perhaps,
appropriate to consider what its terms of reference should be, and the breadth of its interests …

A statistical method of calculation has been adapted to fitting a theoretical equation to drug
blood level data. This allows calculation by a least squares method of the apparent first …

Captopril, the first orally active inhibitor of angiotensin-converting enzyme, is used widely in
the treatment of hypertension and congestive heart failure. The pharmacokinetics of this …