Comparative lipophilia of trandolapril and other converting enzyme inhibitors
N Genes, G Lemoine, A Duguet, L Vaur, G Moreau… - Therapie, 1995 - europepmc.org
The lipophilicity of angiotensin converting enzyme inhibitors (ACE-I) available in France has
been compared using two complementary methods. Studies have been performed both on …
been compared using two complementary methods. Studies have been performed both on …
Effective serum concentration and action in pharmacokinetics
P Koeppe - Pharmacologia Clinica, 1970 - Springer
A formula has been derived for the calculation of “effective” serum concentration based on
the assumption of both exponential absorption and exponential elimination of an …
the assumption of both exponential absorption and exponential elimination of an …
Pharmacokinetics and biological effects of captopril and hydrochlorothiazide after acute and chronic administration either alone or in combination in hypertensive …
JF Giudicelli, C Richer, A Mattei - British Journal of Clinical …, 1987 - Wiley Online Library
The pharmacokinetics of free unchanged captopril, total captopril and hydrochlorothiazide
(HCTZ) were investigated in three groups of patients with moderate essential hypertension …
(HCTZ) were investigated in three groups of patients with moderate essential hypertension …
Demonstration of a S-methyl metabolite of captopril in patients undergoing chronic captopril therapy.
OH Drummer, B Jarrott, WJ Louis - Clinical and Experimental …, 1982 - europepmc.org
1. The formation of the S-methyl metabolite of captopril has been demonstrated for the first
time in the urine of five patients receiving chronic captopril therapy. 2. Patients were studied …
time in the urine of five patients receiving chronic captopril therapy. 2. Patients were studied …
Kinetic studies of the pharmacologic response to captopril in rats. II. Hypotensive effect and plasma angiotensin converting enzyme activity
M ENDOH, M SUZUKI, K KATAYAMA… - Journal of …, 1989 - jstage.jst.go.jp
抄録 The effect of captopril on the mean arterial blood pressure was studied in rats. Two
different disease-state rats, namely the sodium-deficient rat (SDR) and the two-kidney-one …
different disease-state rats, namely the sodium-deficient rat (SDR) and the two-kidney-one …
Influence of food on the bioavailability of enalapril
BN Swanson, PH Vlasses, RK Ferguson… - Journal of …, 1984 - Elsevier
In a randomized, two-period crossover study in 12 normal volunteers, serum and urine
concentrations of the angiotensin-converting enzyme inhibitor enalapril and its active …
concentrations of the angiotensin-converting enzyme inhibitor enalapril and its active …
[引用][C] Variability of plasma drug concentrations: some observations
DB Jack, MR Wilkins, MJ Kendall, PE Hall - European journal of clinical …, 1983 - Springer
Sir, For some time we have been interested in the factors affecting the variability of plasma
drug concentrations and have made a particular study of betaadrenoceptor blockers (Jack et …
drug concentrations and have made a particular study of betaadrenoceptor blockers (Jack et …
New Pharmacokinetic Methods: L Estimation of Mean Serum Concentration From Trough Serum Concentration
TR Browne, DJ Greenblatt, GK Szabo… - The Journal of …, 1990 - Wiley Online Library
An equation is derived to estimate mean steady state serum concentration (C̄ss) from
trough steady state serum concentration (Cmin) which can be used for drugs with either …
trough steady state serum concentration (Cmin) which can be used for drugs with either …
Captopril kinetics in chronic congestive heart failure
RJ Cody, GL Schaer, AB Covit… - Clinical …, 1982 - Wiley Online Library
We investigated the kinetics of 25 mg Captopril by mouth in 12 patients with congestive
heart failure and correlated them with the hormonal and hemodynamic changes associated …
heart failure and correlated them with the hormonal and hemodynamic changes associated …