Four methods for estimating dosage regimens for drugs exhibiting non-linear
pharmacokinetic behavior (eg, phenytoin) are described and compared. Estimations of …

It is a major goal of clinical pharmacology to understand the dose-effect relationship in
therapeutics. Much progress towards this goal has been made in the last 2 decades through …

THE intensity of the therapeutic and toxic effects of most pharmacologic agents depends on
their concentration at the sites of action. The time course of this concentration is determined …

The preceding paper (1) discusses my earlier criticism, based on pragmatic reasons, of the
paper (2) published by Amirjahed (3). It was suggested by Amirjahed (3) that if only 10 …

Pharmacokinetics, Science or Fiction? Page 1 Pharmacological Research, Vol. 33, No. 4/5,
1996 PHARMACOKINETICS, SCIENCE OR FICTION? ALDO RESCIGNO Institute of …

Although clomiphene has been used extensively in the treatment of anovulation in normal
cycling women for more than 20 years, little is known about the pharmacokinetics of the …

The converting enzyme inhibitor CGS 14824A was evaluated in 15 healthy male volunteers.
First, the efficacy of a single 5 or 10 mg oral dose in antagonizing the pressor response to …

The study of enzyme kinetics in drug metabolism involves assessment of rates of
metabolism and inhibitory potencies over a suitable concentration range. In all but the very …

A transformation factor is described which related in vitro drug dissolution from a preparation
to the corresponding in vivo plasma drug concentrations. This factor, derived from the …

This year, 2006, marks the 30th anniversary of dren [3] and pregnant women;[4] patients with
various the arrival of Clinical Pharmacokinetics onto the disease states including renal and …