Integration of donor mesenchymal stem cell-derived neuron-like cells into host neural network after rat spinal cord transection
X Zeng, XC Qiu, YH Ma, JJ Duan, YF Chen, HY Gu… - Biomaterials, 2015 - Elsevier
Functional deficits following spinal cord injury (SCI) primarily attribute to loss of neural
connectivity. We therefore tested if novel tissue engineering approaches could enable …
connectivity. We therefore tested if novel tissue engineering approaches could enable …
The integration of NSC-derived and host neural networks after rat spinal cord transection
BQ Lai, JM Wang, JJ Duan, YF Chen, HY Gu, EA Ling… - Biomaterials, 2013 - Elsevier
Rebuilding structures that can bridge the injury gap and enable signal connection remains a
challenging issue in spinal cord injury. We sought to determine if genetically enhanced …
challenging issue in spinal cord injury. We sought to determine if genetically enhanced …
Graft of a tissue-engineered neural scaffold serves as a promising strategy to restore myelination after rat spinal cord transection
BQ Lai, JM Wang, EA Ling, JL Wu… - Stem cells and …, 2014 - liebertpub.com
Remyelination remains a challenging issue in spinal cord injury (SCI). In the present study,
we cocultured Schwann cells (SCs) and neural stem cells (NSCs) with overexpression of …
we cocultured Schwann cells (SCs) and neural stem cells (NSCs) with overexpression of …
[HTML][HTML] Recovery of paralyzed limb motor function in canine with complete spinal cord injury following implantation of MSC-derived neural network tissue
GH Wu, HJ Shi, MT Che, MY Huang, QS Wei, B Feng… - Biomaterials, 2018 - Elsevier
We have reported previously that bone marrow mesenchymal stem cell (MSC)-derived
neural network scaffold not only survived in the injury/graft site of spinal cord but also served …
neural network scaffold not only survived in the injury/graft site of spinal cord but also served …
Donor mesenchymal stem cell-derived neural-like cells transdifferentiate into myelin-forming cells and promote axon regeneration in rat spinal cord transection
XC Qiu, H Jin, RY Zhang, Y Ding, X Zeng… - Stem cell research & …, 2015 - Springer
Introduction Severe spinal cord injury often causes temporary or permanent damages in
strength, sensation, or autonomic functions below the site of the injury. So far, there is still no …
strength, sensation, or autonomic functions below the site of the injury. So far, there is still no …
Transplantation of tissue engineering neural network and formation of neuronal relay into the transected rat spinal cord
BQ Lai, MT Che, BL Du, X Zeng, YH Ma, B Feng… - Biomaterials, 2016 - Elsevier
Severe spinal cord injury (SCI) causes loss of neural connectivity and permanent functional
deficits. Re-establishment of new neuronal relay circuits after SCI is therefore of paramount …
deficits. Re-establishment of new neuronal relay circuits after SCI is therefore of paramount …
Cograft of neural stem cells and schwann cells overexpressing TrkC and neurotrophin-3 respectively after rat spinal cord transection
JM Wang, YS Zeng, JL Wu, Y Li, YD Teng - Biomaterials, 2011 - Elsevier
Effectively bridging the lesion gap is still an unmet demand for spinal cord repair. In the
present study, we tested our hypothesis if cograft of Schwann cells (SCs) and neural stem …
present study, we tested our hypothesis if cograft of Schwann cells (SCs) and neural stem …
Graft of the gelatin sponge scaffold containing genetically‐modified neural stem cells promotes cell differentiation, axon regeneration, and functional recovery in rat …
BL Du, X Zeng, YH Ma, BQ Lai… - … Research Part A, 2015 - Wiley Online Library
Biological materials combined with genetically‐modified neural stem cells (NSCs) are
candidate therapy targeting spinal cord injury (SCI). Based on our previous studies, here we …
candidate therapy targeting spinal cord injury (SCI). Based on our previous studies, here we …
Neurotrophin-3 gene-modified Schwann cells promote TrkC gene-modified mesenchymal stem cells to differentiate into neuron-like cells in poly (lactic-acid-co …
Y Zhang, L He, B Xing, X Zeng, C Zeng, W Zhang… - Cells Tissues …, 2012 - karger.com
Rapid progress in the field of nerve tissue engineering has opened up the way for new
therapeutic strategies for spinal cord injury (SCI). Bone marrow-derived mesenchymal stem …
therapeutic strategies for spinal cord injury (SCI). Bone marrow-derived mesenchymal stem …
Direct neuronal differentiation of neural stem cells for spinal cord injury repair
W Xue, C Fan, B Chen, Y Zhao, Z Xiao, J Dai - Stem Cells, 2021 - academic.oup.com
Spinal cord injury (SCI) typically results in long-lasting functional deficits, largely due to
primary and secondary wh ite matter damage at the site of injury. The transplantation of …
primary and secondary wh ite matter damage at the site of injury. The transplantation of …
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