Results Inhibition of NK Cell Cytotoxicity. To determine the effects of mAb treatment on both
in vivo and in vitro derived NK cells, the cytotoxicity of F344 unfractionated and nylon wool …

Results Phenotypic Characterization of mAb. In the present study, three mAb were chosen
for analysis of their binding to various effector cell populations (mAb designated 5C6, 6D3. 2 …

A sensitive target binding assay has recently been shown to detect natural killer (NK) cells in
the mouse. Preincubation of NK cells with detergent-solubilized cell-surface proteins of YAC …

Natural killer (NK) cells are considered to play an important role in tumor surveillance. The
killing of tumor target cells by NK cells is the result of a complex series of sequential binding …

Publisher Summary This chapter discusses the specificity of natural killer cells and nature of
target cell structures. NK cells have now demonstrated the killing of a wide variety of …

A number of simple sugars have been tested and found to be effective in blocking lysis of
YAC-1 tumor target cells by nonimmune murine natural killer (NK) effector cells. Using a …

Natural killer cells (NK) constitute a minor lymphoid population distinct from T and B cells
which express a non-major histocompatability complex (MHC)-restricted lytic activity. The …

Natural killer (NK) cells are defined as CD3, T cell receptor (TCR) negative, CD16*, CD56+,
large granular lymphocytes (LGL) capable of killing tumor targets in a non-major …

Tumor target cells (TC) are lysed by natural killer (NK) cells provided that they (1) form
conjugates with the effector cells,(2) activate effector cells to release cytotoxic factors, and …

Abstract mAb have been derived against NK cell-sensitive target cells in an effort to identify
the target cell structure involved in Ag recognition by NK cells. Several mAb were selected …