The availability of paracrine factors in the islets of Langerhans, and the constitution of the
beta cell basement membrane can both be affected by proteolytic enzymes. This study …

Pancreatic islet formation is a highly regulated process that is initiated at the end of gestation
in rodents. Endocrine precursor cells first form within the epithelium of duct-like structures …

Matrix metalloproteinases (MMPs) are involved in the regulation of extracellular matrix
turnover and tissue remodeling, through which they can influence the infiltration of a graft by …

Background: Pancreatic fibrosis is a characteristic feature of chronic pancreatic injury and is
thought to result from a change in the balance between synthesis and degradation of …

Islet transplantation provides an approach to compensate for loss of insulin-producing cells
in patients with type 1 diabetes. However, the intraportal route of transplantation is …

Islets of Langerhans are microorgans scattered throughout the pancreas, and are
responsible for synthesizing and secreting pancreatic hormones. While progress has …

To assess the molecular changes associated with pancreatic β-cell dysfunction occurring
during the onset of type 2 diabetes, we profiled pancreatic islet mRNAs from diabetic male …

Activation of matrix metalloproteinase (MMP)-2, the 72-kd collagenase IV/gelatinase A, is
involved in extracellular matrix remodeling. It has been suggested that a membrane-type …

Matrix metalloproteinases, in particular gelatinase B/MMP‐9, are key mediators in
autoimmune diseases like multiple sclerosis and rheumatoid arthritis, but their pathogenic …

This study was performed to follow up on the observation that gelatinase A (MMP-2)
deficiency impairs adipose tissue development in mice. The aim was to evaluate the role of …