Autophagy is designated as a biological recycling process to maintain cellular homeostasis
by the sequestration of damaged proteins and organelles in plasma and cargo delivery to …

Bone homeostasis is maintained by bone remodeling, which involves continuous bone
resorption by osteoclasts and bone formation by osteoblasts. Dysregulation of bone …

Forkhead box protein A2 (FOXA2) is a core transcription factor that controls cell
differentiation and may have an important role in bone metabolism. However, the role of …

Uncontrolled oxidative stress impairs bone formation and induces age‐related bone loss in
humans. The FoxO family is widely accepted to play an important role in protecting diverse …

It is a great challenge to develop a safe and effective treatment strategy for age-related
osteoporosis and fracture healing. As one of the four FOXO transcription factors, FOXO1 is …

Mitochondrial components have been abundantly detected in bone matrix, implying that they
are somehow transported extracellularly to regulate osteogenesis. Here, we demonstrate …

Aging increases oxidative stress and osteoblast apoptosis and decreases bone mass,
whereas forkhead box O (FoxO) transcription factors defend against oxidative stress by …

Doxorubicin (DOX), a widely used chemotherapeutic agent, has been linked to an increased
risk of bone damage in human patients and induces bone loss in mice. DOX induces …

Objective The forkhead box O1 (FOXO1) transcription factor is a key regulator of autophagy.
In chondrocytes, reduced FOXO1 expression with aging causes osteoarthritis due to …

Autophagy is vital for maintaining cellular homeostasis through removing impaired
organelles. It has recently been found to play pivotal roles in diabetes mellitus (DM), which is …