GABA type A receptors (GABAARs) mediate the majority of fast inhibitory neurotransmission
in the central nervous system (CNS). Most prevalent as heteropentamers composed of two …

Aim: In Alzheimer's disease (AD) it is well known that specific regions of the brain are
particularly vulnerable to the pathologic insults of the disease. In particular, the …

Down syndrome (DS) is a genetic disease with developmental brain abnormalities resulting
in early mental retardation and precocious, age-dependent Alzheimer-type …

Age and sex are risk factors of Alzheimer's disease (AD). Among the neurotransmitter
systems, gamma-aminobutyric acid (GABA) has been implicated in AD pathogenesis but the …

Amyloid plaques and tau tangles are common pathological hallmarks for Alzheimer's
disease (AD); however, reducing Aβ production failed to relieve the symptoms of AD …

Background Neuronal hyperactivity related to β-amyloid (Aβ) is considered an early warning
sign of Alzheimer disease (AD). Although increasing evidence supports this opinion, the …

Objective To propose a new hypothesis that GABAergic dysfunction in excitatory and
inhibitory (E/I) imbalance drives the pathogenesis of Alzheimer's disease (AD). Background …

Considering the mechanisms responsible for age-and Alzheimer's disease (AD)-related
neuronal degeneration, little attention was paid to the opposing relationships between the …

Astrocytes are the most abundant glial cells in the central nervous system (CNS) mediating a
variety of homeostatic functions, such as spatial K+ buffering or neurotransmitter reuptake. In …

This review presents a brief overview of the γ-aminobutyric acid (GABA) system in the
developing and mature central nervous system (CNS) and its potential connections to …