Since it was first generally accepted that the two amino acids glutamate and GABA act as
principal neurotransmitters, several landmark discoveries relating to this function have been …

Synaptic transmission is closely linked to brain energy and neurotransmitter metabolism.
However, the extent of brain metabolism of the inhibitory neurotransmitter γ‐aminobutyric …

Alzheimer's disease (AD), the most common cause of dementia, is a progressive
neurodegenerative disease. The number of AD cases has been rapidly growing worldwide …

Neuroinflammation, oxidative stress, decreased glucose/energy metabolism, and disrupted
neurotransmission are changes that occur early in sporadic Alzheimer's disease (AD) …

Neural functioning and plasticity can be studied on different levels of organization and
complexity ranging from the molecular and synaptic level to neural circuitry of whole brain …

Alzheimer's disease (AD) is the leading type of dementia worldwide. With an increasing
burden of an aging population coupled with the lack of any foreseeable cure, AD warrants …

γ-Aminobutyric acid (GABA) synthesis from glutamate is catalyzed by glutamate
decarboxylase (GAD) of which two isoforms, GAD65 and GAD67, have been identified. The …

Alzheimer's disease (AD) is a progressive degenerative neurological illness with insidious
onset. Due to the complexity of the pathogenesis of AD and different pathological changes …

Glutamate recycling between neurons and astrocytes is essential to maintain
neurotransmitter homeostasis. Disturbances in glutamate homeostasis, resulting in …

Alzheimer's disease (AD) is an irreversible brain disorder associated with slow, progressive
loss of brain functions mostly in older people. The disease processes start years before the …