Protective immunity against tularemia provided by an adenovirus-vectored vaccine expressing Tul4 of Francisella tularensis

R Kaur, S Chen, MT Arévalo, Q Xu… - Clinical and Vaccine …, 2012 - Am Soc Microbiol
Francisella tularensis, a category A bioterrorism agent, is a highly infectious organism that is
passed on via skin contact and inhalation routes. A live attenuated vaccine strain (LVS) has …

Epitope-based vaccination against pneumonic tularemia

SH Gregory, S Mott, J Phung, J Lee, L Moise… - Vaccine, 2009 - Elsevier
Francisella tularensis, the etiological agent of tularemia, is one of the most infectious
bacterial pathogens known. No vaccine is currently approved for public use. Previously, we …

Alginate microencapsulation of an attenuated O-antigen mutant of Francisella tularensis LVS as a model for a vaccine delivery vehicle

KC Freudenberger Catanzaro, KK Lahmers, IC Allen… - Plos one, 2022 - journals.plos.org
Francisella tularensis is the etiologic agent of tularemia and a Tier I Select Agent.
Subspecies tularensis (Type A) is the most virulent of the four subspecies and inhalation of …

Tularemia vaccine: past, present and future

PCF Oyston, JE Quarry - Antonie Van Leeuwenhoek, 2005 - Springer
Francisella tularensis is a Gram negative intracellular pathogen that causes the highly
debilitating or fatal disease tularemia. F. tularensis can infect a wide range of animals and …

Successful protection against tularemia in C57BL/6 mice is correlated with expansion of Francisella tularensis-specific effector T cells

AJ Griffin, DD Crane, TD Wehrly… - Clinical and Vaccine …, 2015 - Am Soc Microbiol
Francisella tularensis is an intracellular, Gram-negative bacterium that causes the fatal
disease tularemia. Currently, there are no licensed vaccines for tularemia and the …

Toll-like receptor 4 (TLR4) does not confer a resistance advantage on mice against low-dose aerosol infection with virulent type A Francisella tularensis

W Chen, R KuoLee, H Shen, M Bùsa, JW Conlan - Microbial pathogenesis, 2004 - Elsevier
Francisella tularensis, the causative agent of tularemia, is a gram-negative facultative
intracellular bacterium. Toll-like receptor (TLR) 4 is considered to be critical for inducing host …

Rapid Local Expression of Interleukin-12, Tumor Necrosis Factor Alpha, and Gamma Interferon after CutaneousFrancisella tularensis Infection in Tularemia-Immune …

S Stenmark, D Sunnemark, A Bucht… - Infection and …, 1999 - Am Soc Microbiol
Francisella tularensis LVS is an effective live vaccine strain used for cutaneous vaccination
against tularemia in man. In mice, injection of LVS causes invasive disease and subsequent …

Immunotherapy for tularemia

JA Skyberg - Virulence, 2013 - Taylor & Francis
Francisella tularensis is a gram-negative bacterium that causes the zoonotic disease
tularemia. Francisella is highly infectious via the respiratory route (~ 10 CFUs) and …

From rabbits to humans: the contributions of Dr. Theodore E. Woodward to tularemia research

AS Cross, FM Calia, R Edelman - Clinical infectious diseases, 2007 - academic.oup.com
Tularemia is an endemic zoonotic infection caused by Francisella tularensis, which primarily
causes infection in humans who have handled contaminated animal tissue or have been …

Activities of murine peripheral blood lymphocytes provide immune correlates that predict Francisella tularensis vaccine efficacy

R De Pascalis, L Mittereder, NJ Kennett… - Infection and …, 2016 - Am Soc Microbiol
We previously identified potential correlates of vaccine-induced protection against
Francisella tularensis using murine splenocytes and further demonstrated that the relative …