Genetic basis for the cooperative bioactivation of plant lignans by Eggerthella lenta and other human gut bacteria
Plant-derived lignans, consumed daily by most individuals, are thought to protect against
cancer and other diseases; however, their bioactivity requires gut bacterial conversion to …
cancer and other diseases; however, their bioactivity requires gut bacterial conversion to …
Systems biology elucidates the distinctive metabolic niche filled by the human gut microbe Eggerthella lenta
Human gut bacteria perform diverse metabolic functions with consequences for host health.
The prevalent and disease-linked Actinobacterium Eggerthella lenta performs several …
The prevalent and disease-linked Actinobacterium Eggerthella lenta performs several …
Enterolignan-producing phenotypes are associated with increased gut microbial diversity and altered composition in premenopausal women in the United States
Background: Lignans in plant foods are metabolized by gut bacteria to the enterolignans,
enterodiol (END) and enterolactone (ENL). Enterolignans have biologic activities important …
enterodiol (END) and enterolactone (ENL). Enterolignans have biologic activities important …
[HTML][HTML] Colonic mucosal and exfoliome transcriptomic profiling and fecal microbiome response to a flaxseed lignan extract intervention in humans
Background Microbial metabolism of lignans from high-fiber plant foods produces bioactive
enterolignans, such as enterolactone (ENL) and enterodiol (END). Enterolignan exposure …
enterolignans, such as enterolactone (ENL) and enterodiol (END). Enterolignan exposure …
Phylogeny of human intestinal bacteria that activate the dietary lignan secoisolariciresinol diglucoside
T Clavel, G Henderson, W Engst… - FEMS microbiology …, 2006 - academic.oup.com
The human intestinal microbiota is essential for the conversion of the dietary lignan
secoisolariciresinol diglucoside (SDG) via secoisolariciresinol (SECO) to the enterolignans …
secoisolariciresinol diglucoside (SDG) via secoisolariciresinol (SECO) to the enterolignans …
The edible plant microbiome represents a diverse genetic reservoir with functional potential in the human host
Plant microbiomes have been extensively studied for their agricultural relevance on growth
promotion and pathogenesis, but little is known about their role as part of the diet when fresh …
promotion and pathogenesis, but little is known about their role as part of the diet when fresh …
Toward engineering the metabolic pathways of cancer-preventing lignans in cereal grains and other crops
Lignans, ubiquitous constituents of vascular plants, have a number of properties that are of
use to humans: some can protect against the onset of various cancers, 1 whereas others …
use to humans: some can protect against the onset of various cancers, 1 whereas others …
Bacterial transformation of dietary lignans in gnotobiotic rats
A Woting, T Clavel, G Loh, M Blaut - FEMS microbiology ecology, 2010 - academic.oup.com
The bioactivity of lignans depends on their transformation by gut bacteria. The intestinal
bacteria Clostridium saccharogumia, Eggerthella lenta, Blautia producta and Lactonifactor …
bacteria Clostridium saccharogumia, Eggerthella lenta, Blautia producta and Lactonifactor …
Roles of plant-associated microbiota in traditional herbal medicine
W Huang, C Long, E Lam - Trends in Plant Science, 2018 - cell.com
The microbiome of medicinal plants may directly impact the metabolome of the host, and
thus could influence the efficacy of herbal medicine. We advocate a herb for traditional …
thus could influence the efficacy of herbal medicine. We advocate a herb for traditional …
Interplay between lignans and gut microbiota: nutritional, functional and methodological aspects
Lignans are non-flavonoid polyphenols present in a wide range of foods frequently
consumed in the Western world, such as seeds, vegetables and fruits, and beverages such …
consumed in the Western world, such as seeds, vegetables and fruits, and beverages such …