Cervical cancer represents one of the most important malignancies among women
worldwide. Current therapeutic approaches for cervical cancer are reported not only to be …

OBJECTIVE: Gynecologic cancer is still the third leading cause of cancer death among
women in the US. Therapeutics employing novel mechanisms of action are therefore …

Therapeutic oncolytic viruses: clinical advances and future... : Current Opinion in Oncology
Therapeutic oncolytic viruses: clinical advances and future directions : Current Opinion in …

Cervical cancer is the fourth most common female cancer worldwide and results in over 300
000 deaths globally. The causative agent of cervical cancer is persistent infection with high …

The use of oncolytic viruses to treat cancer is based on the selection of tropic tumor viruses
or the generation of replication selective vectors that can either directly kill infected tumor …

In the past 5 years, the field of oncolytic virus research has matured significantly and is
moving past the stage of being a laboratory novelty into a new era of preclinical and clinical …

Oncolytic viruses are naturally occurring or genetically engineered viruses that can replicate
preferentially in tumor cells and inhibit tumor growth. These viruses have been considered …

Leveraging the immune system to thwart cancer is not a novel strategy and has been
explored via cancer vaccines and use of immunomodulators like interferons. However, it …

Oncolytic viruses are biologic agents able to selectively infect and destroy cancer cells while
sparing the normal ones. Furthermore, they also stimulate the host immune system to …

The field of oncolytic virus therapy, the use of live, replicating viruses for the treatment of
cancer, has expanded rapidly over the past decade. Preclinical models have clearly …