Pulmonary hypertension (PH) is a fatal disease with no treatment options, characterised by
elevated pulmonary vascular resistanzce and secondary right ventricular failure. The …

Rationale: Pulmonary arterial hypertension (PAH) is a severe disease characterized by an
increase of pulmonary vascular resistance, which is accompanied by functional and …

Rationale: Circulating microparticles (MPs) are submicron membrane fragments shed from
damaged or activated vascular cells. Endothelial MPs are a biological marker of …

Abstract Background Microparticles (MPs) stimulate inflammatory adhesion molecule
expression in systemic vascular diseases, however it is unknown whether circulating MPs …

Eur J Clin Invest 2012 Abstract Background The various aetiologies and risk factors for
pulmonary arterial hypertension (PAH) lead to close phenotypes with small differences …

Rationale: Procoagulant microparticles constitute valuable hallmarks of cell damage.
Microparticles also behave as cellular effectors. Objectives: We hypothesized that the extent …

Highlights•Thrombosis and excess platelet activation are key pathologic features of
pulmonary arterial hypertension (PAH).•Platelets are the main source of circulating …

Background and objective Endothelial microparticles (EMP) are submicron vesicles
released from endothelial cells. We aimed to determine the utility of EMP as biomarkers of …

Cell-derived microparticles are small (0.1–1 μm) vesicles shed by most eukaryotic cells
upon activation or during apoptosis. Microparticles carry on their surface, and enclose within …

Pulmonary hypertension (PH) is associated with platelet activation, vascular inflammation
and endothelial dysfunction leading to often life threatening thrombo-embolic complications …