Blood vessels perfuse all tissues in the body and mediate vital metabolic exchange between
tissues and blood. Increasing evidence, however, points to a direct role for paracrine …

The establishment and maintenance of the vascular system is critical for embryonic
development and postnatal life. Defects in endothelial cell development and vessel …

The formation and remodeling of a functional circulatory system is critical for sustaining
prenatal and postnatal life. During embryogenesis, newly differentiated endothelial cells …

The maturation of nascent vasculature, formed by vasculogenesis or angiogenesis, requires
recruitment of mural cells, generation of an extracellular matrix and specialization of the …

The endothelium is capable of remarkable plasticity. In the embryo, primitive endothelial
cells differentiate to acquire arterial, venous or lymphatic fates. Certain endothelial cells also …

The endothelium is composed of specialized epithelial cells that line the vasculature, the
lymph vessels, and the heart. These endothelial cells are characterized by their stratification …

The formation of new blood vessels in the adult organism not only contributes to the
progression of diseases such as cancer and diabetic retinopathy but also can be promoted …

Endothelial cells adopt tissue-specific characteristics to instruct organ development and
regeneration,. This adaptability is lost in cultured adult endothelial cells, which do not …

▪ Abstract Regulated assembly of a highly specialized interconnecting network of vascular
endothelial and supportive cells is fundamental to embryonic development and …

The intricate patterning processes that establish the complex vascular system during
development depend on a combination of intrinsic pre-patterning and extrinsic responses to …