Context-dependent roles of complement in cancer
LT Roumenina, MV Daugan, F Petitprez… - Nature Reviews …, 2019 - nature.com
The tumour microenvironment (TME) highly influences the growth and spread of tumours,
thus impacting the patient's clinical outcome. In this context, the complement system plays a …
thus impacting the patient's clinical outcome. In this context, the complement system plays a …
Complement system: promoter or suppressor of cancer progression?
M Revel, MV Daugan, C Sautés-Fridman, WH Fridman… - Antibodies, 2020 - mdpi.com
Constituent of innate immunity, complement is present in the tumor microenvironment. The
functions of complement include clearance of pathogens and maintenance of homeostasis …
functions of complement include clearance of pathogens and maintenance of homeostasis …
The role of complement in tumor growth
R Pio, L Corrales, JD Lambris - Tumor Microenvironment and Cellular …, 2014 - Springer
Complement is a central part of the immune system that has developed as a first defense
against non-self cells. Neoplastic transformation is accompanied by an increased capacity of …
against non-self cells. Neoplastic transformation is accompanied by an increased capacity of …
Cancer and the complement cascade
MJ Rutkowski, ME Sughrue, AJ Kane, SA Mills… - Molecular Cancer …, 2010 - AACR
Despite significant research on the role of inflammation and immunosurveillance in the
immunologic microenvironment of tumors, little attention has been given to the oncogenic …
immunologic microenvironment of tumors, little attention has been given to the oncogenic …
The complement system in cancer: Ambivalence between tumour destruction and promotion
S Mamidi, S Höne, M Kirschfink - Immunobiology, 2017 - Elsevier
Constituting a part of the innate immune system, the complement system consists of over 50
proteins either acting as part of a 3-branch activation cascade, a well-differentiated …
proteins either acting as part of a 3-branch activation cascade, a well-differentiated …
Complement inhibition in cancer therapy
R Pio, D Ajona, JD Lambris - Seminars in immunology, 2013 - Elsevier
For decades, complement has been recognized as an effector arm of the immune system
that contributes to the destruction of tumor cells. In fact, many therapeutic strategies have …
that contributes to the destruction of tumor cells. In fact, many therapeutic strategies have …
Role of the complement system in the tumor microenvironment
R Zhang, Q Liu, T Li, Q Liao, Y Zhao - Cancer Cell International, 2019 - Springer
The complement system has traditionally been considered a component of innate immunity
against invading pathogens and “nonself” cells. Recent studies have demonstrated the …
against invading pathogens and “nonself” cells. Recent studies have demonstrated the …
Complement in cancer: untangling an intricate relationship
ES Reis, DC Mastellos, D Ricklin… - Nature Reviews …, 2018 - nature.com
In tumour immunology, complement has traditionally been considered as an adjunctive
component that enhances the cytolytic effects of antibody-based immunotherapies, such as …
component that enhances the cytolytic effects of antibody-based immunotherapies, such as …
Is complement good or bad for cancer patients? A new perspective on an old dilemma
MM Markiewski, JD Lambris - Trends in immunology, 2009 - cell.com
Several studies of human cancers have established that chronic and insidious inflammation
promotes the process of carcinogenesis and exacerbates the growth of existing tumors …
promotes the process of carcinogenesis and exacerbates the growth of existing tumors …
Complement system: an immunotherapy target in colorectal cancer
Colorectal cancer (CRC) is the third most common malignant tumor and the second most
fatal cancer worldwide. Several parts of the immune system contribute to fighting cancer …
fatal cancer worldwide. Several parts of the immune system contribute to fighting cancer …