Induction of maturation in cumulus cell‐enclosed mouse oocytes by follicle‐stimulating hormone and epidermal growth factor: Evidence for a positive stimulus of …

SM Downs, SAJ Daniel, JJ Eppig - Journal of Experimental …, 1988 - Wiley Online Library
The efficacy of follicle‐stimulating hormone (FSH), epidermal growth factor (EGF), and
dibutyryl cGMP (dbcGMP) as inducers of germinal vesicle breakdown (GVBD) in cumulus …

Inhibition of oocyte maturation in the mouse: participation of cAMP, steroid hormones, and a putative maturation-inhibitory factor

JJ Eppig, RR Freter, PF Ward-Bailey, RM Schultz - Developmental biology, 1983 - Elsevier
The hypothesis that cumulus cells inhibit oocyte maturation by a cAMP-dependent process
was tested (RM Schultz, R. Montgomery, PF Ward-Bailey, and JJ Eppig (1983). Dev. Biol …

Specificity of epidermal growth factor action on maturation of the murine oocyte and cumulus oophorus in vitro

SM Downs - Biology of Reproduction, 1989 - academic.oup.com
Experiments were carried out to determine the specificity of growth factor action on
maturation of the oocyte-cumulus cell complex in vitro. Cumulus cell-enclosed oocytes …

Culture conditions affect meiotic regulation in cumulus cell‐enclosed mouse oocytes

SM Downs, AM Mastropolo - Molecular Reproduction and …, 1997 - Wiley Online Library
To test the hypothesis that culture conditions influence meiotic regulation in mouse oocytes,
we have examined the effects of six culture media, four organic buffers, and pH on …

FSH-induced expansion of the mouse cumulus oophorus in vitro is dependent upon a specific factor (s) secreted by the oocyte

R Buccione, BC Vanderhyden, PJ Caron… - Developmental biology, 1990 - Elsevier
Although it has been shown that granulosa cells regulate the growth and meiotic maturation
of mammalian oocytes, there is little evidence of a role for the oocyte in the differentiation or …

Effect of follicle-stimulating hormone on cyclic adenosine monophosphate level and on meiotic maturation in mouse cumulus cell-enclosed oocytes cultured in vitro

A Salustri, S Petrungaro, M De Felici… - Biology of …, 1985 - academic.oup.com
We have reported that in vitro treatment with follicle-stimulating hormone (FSH) delays by
about 3 h spontaneous meiotic resumption in cumulus cell-enclosed mouse oocytes. In the …

Developmental capacity of mouse oocytes matured in vitro: effects of gonadotrophic stimulation, follicular origin and oocyte size

JJ Eppig, AC Schroeder, MJ O'brien - Reproduction, 1992 - rep.bioscientifica.com
Development of mammalian oocytes is usually correlated with ovarian follicular
development. This correlation was tested by determining whether gonadotrophic stimulation …

The relationship between cumulus cell-oocyte coupling, oocyte meiotic maturation, and cumulus expansion

JJ Eppig - Developmental Biology, 1982 - Elsevier
The timing of the reduction of cumulus cell-oocyte coupling was correlated with oocyte
meiotic maturation and the expansion (mucification) of the cumulus oophorus using …

Developmental pattern of the secretion of cumulus expansion-enabling factor by mouse oocytes and the role of oocytes in promoting granulosa cell differentiation

BC Vanderhyden, PJ Caron, R Buccione… - Developmental biology, 1990 - Elsevier
The expansion, or mucification, of the mouse cumulus oophorus in vitro requires the
presence of an enabling factor secreted by the oocyte as well as stimulation with follicle …

Gonadotropin stimulation of the expansion of cumulus oophori isolated from mice: General condition for expansion in vitro

JJ Eppig - Journal of Experimental Zoology, 1979 - Wiley Online Library
Abstract Gonadotropin Stimulation of the Expansion of Cumulus Oophori Isolated from Mice:
General Conditions for Expansion In Vitro The hormonal stimulation of cumulus expansion …