VT Mechanisms in LQTS. Both the congenital and acquired long QT syndrome are due to
abnormalities (intrinsic and/or acquired) of the ionic currents underlying repolarization. The …

Long QT syndrome is a disease of delayed ventricular repolarization. It manifests clinically
as recurrent syncope and sudden cardiac death caused by an atypical form of polymorphic …

The long QT syndrome (LQTS) has often been considered as a model to study the
abnormalities of cardiac repolarization in humans because it represents a pure electrical …

We have previously developed a canine in vivo model of the long QT syndrome (LQTS)
using the neurotoxin anthopleurin A (AP-A), which acts by slowing sodium channel …

BACKGROUND: LQTS may cause sudden cardiac death (SCD), but the mechanisms linking
gene mutations to ventricular fibrillation (VF) are unclear. OBJECTIVE: To determine …

Torsades DE POINTES is the captivat-ing expression coined by Dessertenne'and adopted
world-wide to describe the ventricular tachyarrhythmias that occur in the setting of QT …

Introduction: The occurrence of significant spatial dispersion of repolarization in vivo as it
relates to the mechanism of arrhythmia formation in the long QT syndrome (LQTS) continues …

It is becoming clear that mutations in the KVLQT1, human “ether-a-go-go” related gene,
cardiac voltage-dependent sodium channel gene, minK and MiRP1 genes, respectively, are …

The long QT syndrome (LQTS) is a genetic disorder characterized by prolongation of the QT
interval in the electrocardiogram (ECG) and a propensity to torsades de pointes ventricular …

The LQTS is a prime example of how molecular biology, ion channel, cellular, and organ
physiology, coupled with clinical observations, promise to be the future paradigm for …