We have previously described a novel cancer chemotherapeutic approach based on the
induction of apoptosis in targeted cells by homing pro-apoptotic peptides. In order to …

Until recently, most research efforts aimed at developing anti-cancer tools were focusing on
small molecules. Alternative compounds are now being increasingly assessed for their …

Nowadays, cancer has become the second highest leading cause of death, and it is
expected to continue to affect the population in forthcoming years. Additionally, treatment …

Backgrounds Peptide-based drugs have shown promising results in overcoming the
limitations of chemotherapeutic drugs by providing a targeted therapy approach to cancer …

Anticancer peptide (ACP) is a kind of small peptides that can kill cancer cells without
damaging normal cells. In recent years, ACP has been pre-clinically used for cancer …

Peptides derived from the N-terminal and C-terminal regions of the p53 tumor suppressor
protein, linked to the membrane transduction domain of Antennapedia, have both been …

The capacity of cell penetrating peptides (CPPs) to breach biological membranes offers
hope for their utilisation as vectors for the delivery of small molecule drugs and …

Cells in the balance: Programmed cell death is an important and stringently controlled
process. Aberrancies in its control mechanisms can lead to disease; overactive apoptosis …

Background: Therapeutic peptides have great potential as anticancer agents owing to their
ease of rational design and target specificity. However, their utility in vivo is limited by low …

Knowledge of apoptosis proteins plays an important role in understanding the mechanism of
programmed cell death. Thus, annotating the function of apoptosis proteins is of significant …