Positron emission tomography in CNS drug discovery and drug monitoring

M Piel, I Vernaleken, F Rösch - Journal of medicinal chemistry, 2014 - ACS Publications
Molecular imaging methods such as positron emission tomography (PET) are increasingly
involved in the development of new drugs. Using radioactive tracers as imaging probes, PET …

Positron emission tomographic imaging in drug discovery

KK Ghosh, P Padmanabhan, CT Yang, DCE Ng… - Drug Discovery …, 2022 - Elsevier
Positron emission tomography (PET) is an extensively used nuclear functional imaging
technique, especially for central nervous system (CNS) and oncological disorders. Currently …

Positron emission tomography molecular imaging for drug development

PM Matthews, EA Rabiner, J Passchier… - British journal of …, 2012 - Wiley Online Library
Human in vivo molecular imaging with positron emission tomography (PET) enables a new
kind of 'precision pharmacology', able to address questions central to drug development …

PET studies in drug development: methodological considerations

VJ Cunningham, CA Parker, EA Rabiner… - Drug Discovery Today …, 2005 - Elsevier
Positron emission tomography (PET), as an in vivo pharmacological imaging tool in
experimental medicine, is playing an increasing role in drug development. There are two …

Positron emission tomography: applications in drug discovery and drug development

J Wang, L Maurer - Current topics in medicinal chemistry, 2005 - ingentaconnect.com
Positron Emission Tomography (PET) is a sophisticated nuclear imaging modality that
affords researchers the ability to conduct both functional and molecular imaging on …

The application of positron emission tomography (PET) imaging in CNS drug development

I Suridjan, RA Comley, EA Rabiner - Brain imaging and behavior, 2019 - Springer
As drug discovery and development in Neuroscience push beyond symptom management
to disease modification, neuroimaging becomes a key area of translational research that …

Radiopharmaceutical chemistry for positron emission tomography

Z Li, PS Conti - Advanced drug delivery reviews, 2010 - Elsevier
Molecular imaging is an emerging technology that allows the visualization of interactions
between molecular probes and biological targets. Molecules that either direct or are subject …

Using positron emission tomography to facilitate CNS drug development

CM Lee, L Farde - Trends in Pharmacological Sciences, 2006 - cell.com
Positron emission tomography (PET) is a non-invasive technology of nuclear medicine that
has sensitivity for tracing low picomolar concentrations of radiolabeled molecules in the …

Modeling of PET data in CNS drug discovery and development

K Varnäs, A Varrone, L Farde - Journal of pharmacokinetics and …, 2013 - Springer
Positron emission tomography (PET) is increasingly used in drug discovery and
development for evaluation of CNS drug disposition and for studies of disease biomarkers to …

Positron emission tomography and single-photon emission computed tomography in central nervous system drug development

DJ Brooks - NeuroRx, 2005 - Springer
In this review, the value of functional imaging [positron emission tomography (PET)/single-
photon emission computed tomography (SPECT)] in drug development is considered …