Positron emission tomography in CNS drug discovery and drug monitoring
M Piel, I Vernaleken, F Rösch - Journal of medicinal chemistry, 2014 - ACS Publications
Molecular imaging methods such as positron emission tomography (PET) are increasingly
involved in the development of new drugs. Using radioactive tracers as imaging probes, PET …
involved in the development of new drugs. Using radioactive tracers as imaging probes, PET …
Positron emission tomographic imaging in drug discovery
Positron emission tomography (PET) is an extensively used nuclear functional imaging
technique, especially for central nervous system (CNS) and oncological disorders. Currently …
technique, especially for central nervous system (CNS) and oncological disorders. Currently …
Positron emission tomography molecular imaging for drug development
Human in vivo molecular imaging with positron emission tomography (PET) enables a new
kind of 'precision pharmacology', able to address questions central to drug development …
kind of 'precision pharmacology', able to address questions central to drug development …
PET studies in drug development: methodological considerations
VJ Cunningham, CA Parker, EA Rabiner… - Drug Discovery Today …, 2005 - Elsevier
Positron emission tomography (PET), as an in vivo pharmacological imaging tool in
experimental medicine, is playing an increasing role in drug development. There are two …
experimental medicine, is playing an increasing role in drug development. There are two …
Positron emission tomography: applications in drug discovery and drug development
J Wang, L Maurer - Current topics in medicinal chemistry, 2005 - ingentaconnect.com
Positron Emission Tomography (PET) is a sophisticated nuclear imaging modality that
affords researchers the ability to conduct both functional and molecular imaging on …
affords researchers the ability to conduct both functional and molecular imaging on …
The application of positron emission tomography (PET) imaging in CNS drug development
As drug discovery and development in Neuroscience push beyond symptom management
to disease modification, neuroimaging becomes a key area of translational research that …
to disease modification, neuroimaging becomes a key area of translational research that …
Radiopharmaceutical chemistry for positron emission tomography
Z Li, PS Conti - Advanced drug delivery reviews, 2010 - Elsevier
Molecular imaging is an emerging technology that allows the visualization of interactions
between molecular probes and biological targets. Molecules that either direct or are subject …
between molecular probes and biological targets. Molecules that either direct or are subject …
Using positron emission tomography to facilitate CNS drug development
CM Lee, L Farde - Trends in Pharmacological Sciences, 2006 - cell.com
Positron emission tomography (PET) is a non-invasive technology of nuclear medicine that
has sensitivity for tracing low picomolar concentrations of radiolabeled molecules in the …
has sensitivity for tracing low picomolar concentrations of radiolabeled molecules in the …
Modeling of PET data in CNS drug discovery and development
Positron emission tomography (PET) is increasingly used in drug discovery and
development for evaluation of CNS drug disposition and for studies of disease biomarkers to …
development for evaluation of CNS drug disposition and for studies of disease biomarkers to …
Positron emission tomography and single-photon emission computed tomography in central nervous system drug development
DJ Brooks - NeuroRx, 2005 - Springer
In this review, the value of functional imaging [positron emission tomography (PET)/single-
photon emission computed tomography (SPECT)] in drug development is considered …
photon emission computed tomography (SPECT)] in drug development is considered …