Bacteriophage technology and modern medicine

AH Azam, XE Tan, S Veeranarayanan, K Kiga, L Cui - Antibiotics, 2021 - mdpi.com
The bacteriophage (or phage for short) has been used as an antibacterial agent for over a
century but was abandoned in most countries after the discovery and broad use of …

Genetic engineering of bacteriophages: Key concepts, strategies, and applications

W Hussain, X Yang, M Ullah, H Wang, A Aziz… - Biotechnology …, 2023 - Elsevier
Bacteriophages are the most abundant biological entity in the world and hold a tremendous
amount of unexplored genetic information. Since their discovery, phages have drawn a great …

Myriad applications of bacteriophages beyond phage therapy

JC García-Cruz, D Huelgas-Méndez… - PeerJ, 2023 - peerj.com
Bacteriophages are the most abundant biological entity on the planet, having pivotal roles in
bacterial ecology, animal and plant health, and in the biogeochemical cycles. Although, in …

Phage therapy: beyond antibacterial action

A Górski, E Jończyk-Matysiak, R Międzybrodzki… - Frontiers in …, 2018 - frontiersin.org
Until recently, phages were considered as mere “bacteria eaters” with potential for use in
combating antimicrobial resistance. The real value of phage therapy assessed according to …

Phage therapy: combating infections with potential for evolving from merely a treatment for complications to targeting diseases

A Górski, R Międzybrodzki… - Frontiers in …, 2016 - frontiersin.org
Antimicrobial resistance is considered to be one of the greatest challenges of medicine and
our civilization. Lack of progress in developing new anti-bacterial agents has greatly revived …

Applications of designer phage encoding recombinant gene payloads

DS Schmitt, SD Siegel, K Selle - Trends in Biotechnology, 2023 - cell.com
Advances in genetic engineering, synthetic biology, and DNA sequencing have transformed
the re-emergent therapeutic bacteriophage field. The increasing rate of multidrug resistant …

Genetic and chemical engineering of phages for controlling multidrug-resistant bacteria

D Guo, J Chen, X Zhao, Y Luo, M Jin, F Fan, C Park… - Antibiotics, 2021 - mdpi.com
Along with the excessive use of antibiotics, the emergence and spread of multidrug-resistant
bacteria has become a public health problem and a great challenge vis-à-vis the control and …

Phages and their potential to modulate the microbiome and immunity

S Federici, SP Nobs, E Elinav - Cellular & molecular immunology, 2021 - nature.com
Bacteriophages (hence termed phages) are viruses that target bacteria and have long been
considered as potential future treatments against antibiotic-resistant bacterial infection …

Phage therapy in noncommunicable diseases

D Kviatcovsky, R Valdés-Mas, S Federici, E Elinav - Science, 2023 - science.org
Bacteriophages (phages hereafter) are bacterial viruses that were projected, more than a
century ago, to constitute an effective antimicrobial remedy and were widely used as such …

Phages & antibiotic resistance: are the most abundant entities on earth ready for a comeback?

C Hill, S Mills, RP Ross - Future microbiology, 2018 - Taylor & Francis
Bacteriophages, which lost out to antibiotic therapy in the past, may be poised to make a
comeback. Once discarded because of their narrow activity spectrum, it can now be viewed …