Introduction: Osteosarcoma (OS), the most common primary malignant bone tumor, is
currently treated with pre-and postoperative chemotherapy in association with the surgical …

Importance of the field: Osteosarcoma (OS) is the most common primary malignant bone
tumour in children and adolescents. This review focuses on the most promising therapeutic …

Introduction: Advances in the treatment of osteosarcoma (OS) came in the mid-1970s, when
adding chemotherapy to surgery significantly improved patient survival. OS outcomes have …

Introduction: Current treatment of conventional and non-conventional high-grade
osteosarcoma (HGOS) is based on the surgical removal of primary tumor and, when …

Osteosarcoma is the most common primary tumor of bone. Approximately 2/3 of patients
who present with localized osteosarcoma can be expected to be cured of their disease with …

Highlights•Although rare, bone cancers frequently cause death in the pediatric population.•
Osteosarcoma patient survival has plateaued over the last 20 years.•The large tumor …

Introduction: In the early seventies chemotherapy significantly improved survival in
osteosarcoma. Since then minor innovations have occurred although recent years have …

Osteosarcoma is the bone tumor that most commonly affects children, adolescents, and
young adults. Before 1970, treatment primarily included surgical resection. However, the …

Patients who develop osteosarcoma in 2017 receive treatment that remains essentially
unchanged since the 1970s. Outcomes likewise remain largely unimproved. Large …

Introduction: Although chemotherapy is currently indispensable for the treatment of
osteosarcoma, chemotherapy for this rare cancer has not been developed based on …