Adduct of the blistering warfare agent sesquimustard with human serum albumin and its mass spectrometric identification for biomedical verification of exposure

MM Blum, A Richter, M Siegert, H Thiermann… - Analytical and …, 2020 - Springer
Apart from the well-known sulfur mustard (SM), additional sulfur-containing blistering
chemical warfare agents exist. Sesquimustard (Q) is one of them and five times more …

Methionine329 in human serum albumin: A novel target for alkylation by sulfur mustard

M Siegert, F Gandor, A Kranawetvogl… - Drug Testing and …, 2019 - Wiley Online Library
Exposure to the vesicant sulfur mustard (SM) may lead to erythema and blistering. Toxicity of
SM is hypothesized due to the alkylation of DNA bases and nucleophilic amino acid side …

N‐Acetylcysteine as a chemical scavenger for sulfur mustard: New insights by mass spectrometry

M Siegert, A Kranawetvogl… - Drug testing and …, 2018 - Wiley Online Library
The vesicant sulfur mustard (SM) is a banned chemical warfare agent. Although, SM has
been used in combat since WWI, there is no causal therapy currently available. Accordingly …

Synthesis of different glutathione–sulfur mustard adducts of verified and potential biomarkers

A Bielmann, N Sambiagio, N Wehr, S Gerber-Lemaire… - RSC …, 2018 - pubs.rsc.org
Sulfur Mustard (SM) is a blistering agent used as a chemical weapon. Glutathione (GSH) is
involved in the β-lyase degradation pathway of SM and recently, bioadducts between SM …

An improved method for retrospective quantification of sulfur mustard exposure by detection of its albumin adduct using ultra-high pressure liquid chromatography …

CC Liu, LH Liang, Y Xiang, HL Yu, SK Zhou… - Analytical and …, 2015 - Springer
Sulfur mustard (HD) adduct to human serum albumin (ALB) at Cys-34 residue has become
an important and long-term retrospective biomarker of HD exposure. Here, a novel …

Optimized verification method for detection of an albumin-sulfur mustard adduct at Cys34 using a hybrid quadrupole time-of-flight tandem mass spectrometer after …

H John, M Siegert, F Gandor, M Gawlik… - Toxicology letters, 2016 - Elsevier
The vesicant sulfur mustard (SM) is a banned chemical warfare agent that is controlled by
the Organisation for the Prohibition of Chemical Weapons (OPCW). Bioanalytical …

Evidence of sulfur mustard exposure in human plasma by LC–ESI–MS-MS detection of the albumin-derived alkylated HETE–CP dipeptide and chromatographic …

F Gandor, M Gawlik, H Thiermann… - Journal of Analytical …, 2015 - academic.oup.com
Sulfur mustard (SM) is a chemical warfare agent that causes painful blisters and chemically
modifies endogenous biomacromolecules by alkylation to hydroxyethylthioethyl (HETE) …

Development of a liquid chromatography-multiple reaction monitoring procedure for concurrent verification of exposure to different forms of mustard agents

TH Yeo, ML Ho, WK Loke - Journal of analytical toxicology, 2008 - academic.oup.com
A novel liquid chromatography-multiple reaction monitoring (LC-MRM) procedure has been
developed for retrospective diagnosis of exposure to different forms of mustard agents. This …

An enhanced throughput method for quantification of sulfur mustard adducts to human serum albumin via isotope dilution tandem mass spectrometry

TM Andacht, BG Pantazides, BS Crow… - Journal of analytical …, 2014 - academic.oup.com
Here, we report an enhanced throughput method for the diagnosis of human exposure to
sulfur mustard. A hydroxyethylthioethyl (HETE) ester-adducted tripeptide, produced by …

Evidence of sulfur mustard poisoning by detection of the albumin‐derived dipeptide biomarker C (‐HETE) P after nicotinylation

H John, A Richter, H Thiermann - Drug Testing and Analysis, 2021 - Wiley Online Library
Abstract Sulfur mustard (SM, bis [2‐chloroethyl]‐sulfide) is a banned chemical warfare agent
that was frequently used in recent years and led to numerous poisoned victims who …