Herpes simplex virus 2 virion host shutoff endoribonuclease activity is required to disrupt stress granule formation

RL Finnen, M Zhu, J Li, D Romo, BW Banfield - Journal of virology, 2016 - Am Soc Microbiol
We previously established that cells infected with herpes simplex virus 2 (HSV-2) are
disrupted in their ability to form stress granules (SGs) in response to oxidative stress and that …

The herpes simplex virus 2 virion-associated ribonuclease vhs interferes with stress granule formation

RL Finnen, TJM Hay, B Dauber, JR Smiley… - Journal of …, 2014 - Am Soc Microbiol
In a previous study, it was observed that cells infected with herpes simplex virus 2 (HSV-2)
failed to accumulate stress granules (SGs) in response to oxidative stress induced by …

Herpes simplex virus 2 infection impacts stress granule accumulation

RL Finnen, KR Pangka, BW Banfield - Journal of virology, 2012 - Am Soc Microbiol
Interference with stress granule (SG) accumulation is gaining increased appreciation as a
common strategy used by diverse viruses to facilitate their replication and to cope with …

Defining the role of stress granules in innate immune suppression by the herpes simplex virus 1 endoribonuclease VHS

HM Burgess, I Mohr - Journal of virology, 2018 - Am Soc Microbiol
In response to virus-induced shutoff host protein synthesis, dynamic aggregates containing
mRNA, RNA-binding proteins and translation factors termed stress granules (SGs) often …

Translational arrest and mRNA decay are independent activities of alphaherpesvirus virion host shutoff proteins

L Eke, A Tweedie, S Cutts… - Journal of General …, 2024 - microbiologyresearch.org
The herpes simplex virus 1 (HSV1) virion host shutoff (vhs) protein is an endoribonuclease
that regulates the translational environment of the infected cell, by inducing the degradation …

The herpes simplex virus virion host shutoff protein enhances translation of viral true late mRNAs independently of suppressing protein kinase R and stress granule …

B Dauber, D Poon, T Dos Santos, BA Duguay… - Journal of …, 2016 - Am Soc Microbiol
The herpes simplex virus (HSV) virion host shutoff (vhs) RNase destabilizes cellular and
viral mRNAs, suppresses host protein synthesis, dampens antiviral responses, and …

The virion host shutoff function of herpes simplex virus degrades the 5′ end of a target mRNA before the 3′ end

BM Karr, GS Read - Virology, 1999 - Elsevier
During lytic infections, the virion host shutoff (vhs) function of herpes simplex virus (HSV)
disaggregates host polysomes and induces rapid turnover of both cellular and viral mRNAs …

The herpes simplex virus type 1 vhs-UL41 gene secures viral replication by temporarily evading apoptotic cellular response to infection: Vhs-UL41 activity might …

A Barzilai, I Zivony-Elbom, R Sarid, E Noah… - Journal of …, 2006 - Am Soc Microbiol
We have previously shown that herpes simplex virus type 1 (HSV-1) infection is associated
with early destabilization/degradation of infected cell mRNAs and consequent shutoff of host …

Hiding in plain sight: formation and function of stress granules during microbial infection of mammalian cells

A Tweedie, T Nissan - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
Stress granule (SG) formation is a host cell response to stress-induced translational
repression. SGs assemble with RNA-binding proteins and translationally silent mRNA. SGs …

Sequestration of G3BP coupled with efficient translation inhibits stress granules in Semliki Forest virus infection

MD Panas, M Varjak, A Lulla, K Er Eng… - Molecular biology of …, 2012 - Am Soc Cell Biol
Dynamic, mRNA-containing stress granules (SGs) form in the cytoplasm of cells under
environmental stresses, including viral infection. Many viruses appear to employ …