Abstract In contrast to 5-methylcytosine (5-mC), which has been studied extensively,,, little is
known about 5-hydroxymethylcytosine (5-hmC), a recently identified epigenetic modification …

Abstract Recently, 5-hydroxymethylcytosine (5hmC) was identified in mammalian genomic
DNA. The biological role of this modification remains unclear; however, identifying the …

hydroxymethylcytosine (5hmC) is a recently discovered base in the mammalian genome,
produced upon oxidation of 5-methylcytosine (5mC) in a process catalyzed by TET proteins …

Abstract The 5-methylcytosine (5-mC) derivative 5-hydroxymethylcytosine (5-hmC) is
abundant in the brain for unknown reasons. Here we characterize the genomic distribution …

Hydroxymethylcytosine (hmC) was recently discovered as a new constituent of mammalian
DNA. Besides 5‐methylcytosine (mC), it is the only other modified base in higher organisms …

A complete understanding of the potential function of 5-hydroxymethylcytosine (5-hmC), a
DNA cytosine modification in mammalian cells, requires an accurate single-base resolution …

Methylation at the 5-position of cytosine is a well-studied epigenetic pathway. In addition to 5-
methylcytosine (5mC), substantial amounts of 5-hydroxymethylcytosine (5hmC) also referred …

Summary The study of 5-hydroxylmethylcytosines (5hmC) has been hampered by the lack of
a method to map it at single-base resolution on a genome-wide scale. Affinity purification …

Hydroxymethylcytosine (5hmC) is an important epigenetic mark that regulates gene
expression. Charting the landscape of 5hmC in human tissues is fundamental to …

Hydroxymethylcytosine (hmC) is an oxidation product of 5-methylcytosine which is present
in the deoxyribonucleic acid (DNA) of most mammalian cells. Reduction of hmC levels in …