Streptococcal superantigen (SSA) is a 28,000 M r toxin originally isolated from a pathogenic
strain of Streptococcus pyogenes that has 60% sequence identity with staphylococcal …

Bacterial superantigens are small proteins that have a very potent stimulatory effect on T
lymphocytes through their ability to bind to both MHC class II molecules and T-cell receptors …

MHC class II molecules possess two binding sites for bacterial superantigens (SAGs): a low-
affinity site on the α chain and a high-affinity, zinc-dependent site on the β chain. Only the …

The protein toxins known as superantigens (SAgs), which are expressed primarily by the
pathogenic bacteria Staphylococcus aureus and Streptococcus pyogenes, are highly potent …

Bacterial superantigens (SAgs) are a structurally related group of protein toxins secreted by
Staphylococcus aureus and Streptococcus pyogenes. They are implicated in a range of …

Staphylococcal enterotoxin B is a member of a family of toxins known as superantigens that
activate a large number of T-cells (up to 20%) by cross-linking MHC class II molecules with T …

Superantigens (SAg) bind simultaneously to T-cell receptors (TcR) and major
histocompatibility complex (MHC) class II molecules to activate up to 20 '7'0 of all peripheral …

Superantigens are thought to make external contacts with major histocompatibility complex
(MHC) class II molecules and with the V beta portion of a T cell antigen receptor (TCR) …

Superantigens (SAgs) are bacterial or viral toxins that bind MHC class II (MHC-II) molecules
and T-cell receptor (TCR) in a nonconventional manner, inducing T-cell activation that leads …

The three‐dimensional structure of a bacterial superantigen, Staphylococcus aureus
enterotoxin H (SEH), bound to human major histocompatibility complex (MHC) class II (HLA …