Homocysteine and homocysteine-related compounds: an overview of the roles in the pathology of the cardiovascular and nervous systems

D Djuric, V Jakovljevic, V Zivkovic… - Canadian Journal of …, 2018 - cdnsciencepub.com
Homocysteine, an amino acid containing a sulfhydryl group, is an intermediate product
during metabolism of the amino acids methionine and cysteine. Hyperhomocysteinemia is …

[PDF][PDF] Cardiovascular pathogenesis in hyperhomocysteinemia

T Huang, GF Yuan, ZG Zhang, ZQ Zou… - Asia Pacific journal of …, 2008 - apjcn.nhri.org.tw
Increased plasma homocysteine (Hcy) is a significant and independent risk factor for
cardiovascular disease. It can cause multi-disease manifestations such as smooth muscle …

Homocysteine, intracellular signaling and thrombotic disorders

N Dionisio, I Jardín, GM Salido… - Current Medicinal …, 2010 - ingentaconnect.com
Homocysteine, a sulphur-containing amino acid derived from methionine, has been
presented as an independent risk factor for cardiovascular disorders, including …

Causes of hyperhomocysteinemia and its pathological significance

J Kim, H Kim, H Roh, Y Kwon - Archives of pharmacal research, 2018 - Springer
In the last 10 years, homocysteine has been regarded as a marker of cardiovascular disease
and a definite risk factor for many other diseases. Homocysteine is biosynthesized from …

Hyperhomocysteinemia: clinical insights

F Al Mutairi - Journal of central nervous system disease, 2020 - journals.sagepub.com
Homocysteine (Hcy) is a sulfhydryl-containing amino acid, and intermediate metabolite
formed in metabolising methionine (Met) to cysteine (Cys); defective Met metabolism can …

Roles of homocysteine in cell metabolism: old and new functions

MÁ Medina, JL Urdiales… - European journal of …, 2001 - Wiley Online Library
Mild hyperhomocysteinemia has been suggested as a new, independent risk factor for
cardiovascular disease. This fact has produced a new, increased interest in the study of …

Vascular oxidant stress and inflammation in hyperhomocysteinemia

L Papatheodorou, N Weiss - Antioxidants & redox signaling, 2007 - liebertpub.com
Elevated plasma levels of homocysteine are a metabolic risk factor for atherosclerotic
vascular disease, as shown in numerous clinical studies that linked elevated homocysteine …

Hyperhomocysteinemia: a million ways to lose control

FM Faraci - Arteriosclerosis, thrombosis, and vascular biology, 2003 - Am Heart Assoc
Elevated plasma levels of the amino acid homocysteine increase the risk for atherosclerosis,
stroke, myocardial infarction, and possibly Alzheimer's disease. In relation to vascular …

Mechanisms of homocysteine toxicity in humans

J Perła-Kaján, T Twardowski, H Jakubowski - Amino acids, 2007 - Springer
Homocysteine, a non-protein amino acid, is an important risk factor for ischemic heart
disease and stroke in humans. This review provides an overview of homocysteine influence …

Pathogenesis of vascular disease in hyperhomocysteinaemia

TB Domagala, A Undas, M Libura… - … of cardiovascular risk, 1998 - journals.sagepub.com
Elevated plasma homocysteine is an independent risk factor for atherosclerosis and
thrombosis. The exact mechanism by which homocysteine exerts its atherothrombotic action …