[HTML][HTML] A general-purpose nanohybrid fabricated by polymeric Au (I)-peptide precursor to wake the function of peptide therapeutics

J Yan, F Ji, S Yan, W You, F Ma, F Li, Y Huang… - Theranostics, 2020 - ncbi.nlm.nih.gov
Peptide-derived nanocomposites have been exhibiting fascinating biological advantages,
including but not limited to excellent biocompatibility, biological degradation, high …

A facile approach for synthesis and intracellular delivery of size tunable cationic peptide functionalized gold nanohybrids in cancer cells

K Bansal, M Aqdas, M Kumar, R Bala… - Bioconjugate …, 2018 - ACS Publications
Peptide-based drug delivery systems have become a mainstay in the contemporary
medicinal field, resulting in the design and development of better pharmaceutical …

[HTML][HTML] Awakening p53 in vivo by D-peptides-functionalized ultra-small nanoparticles: Overcoming biological barriers to D-peptide drug delivery

Z Bian, J Yan, S Wang, Y Li, Y Guo, B Ma, H Guo… - Theranostics, 2018 - ncbi.nlm.nih.gov
Peptides are a rapidly growing class of therapeutics with many advantages over
conventional small molecule drugs. Dextrorotary (D)-peptides, with increased enzymatic …

N-Acetylation of Biodegradable Supramolecular Peptide Nanofilaments Selectively Enhances Their Proteolytic Stability for Targeted Delivery of Gold-Based …

Y Marciano, N Nayeem, D Dave, RV Ulijn… - … biomaterials science & …, 2023 - ACS Publications
Peptide materials are promising for various biomedical applications; however, a significant
concern is their lack of stability and rapid degradation in vivo due to non-specific proteolysis …

Self‐assembly of therapeutic peptide into stimuli‐responsive clustered nanohybrids for cancer‐targeted therapy

W He, S Wang, J Yan, Y Qu, L Jin, F Sui… - Advanced functional …, 2019 - Wiley Online Library
Clinical translation of therapeutic peptides, particularly those targeting intracellular protein–
protein interactions (PPIs), has been hampered by their inefficacious cellular internalization …

[HTML][HTML] A nano-predator of pathological MDMX construct by clearable supramolecular gold (I)-thiol-peptide complexes achieves safe and potent anti-tumor activity

S Yan, J Yan, D Liu, X Li, Q Kang, W You, J Zhang… - Theranostics, 2021 - ncbi.nlm.nih.gov
As alternatives to small-molecular proteolysis-targeting chimeras (PROTAC), peptide-based
molecular glues (MG) are a broad range of dual-functional ligands that simultaneously bind …

Reconfigurable peptide nanotherapeutics at tumor microenvironmental pH

ZY Qiao, WJ Zhao, YJ Gao, Y Cong… - … applied materials & …, 2017 - ACS Publications
Peptide nanomaterials have recently attracted considerable interest in the biomedical field.
However, their poor bioavailability and less powerful therapeutic efficacy hamper their …

Cell penetrating peptide (CPP) gold (iii)–complex–bioconjugates: from chemical design to interaction with cancer cells for nanomedicine applications

C Arib, A Griveau, J Eyer, J Spadavecchia - Nanoscale Advances, 2022 - pubs.rsc.org
This study promotes an innovative synthesis of a nanotheragnostic scaffold capable of
targeting and destroying pancreatic cancer cells (PDAC) using the Biotinylated NFL-TBS. 40 …

Multi-domain short peptide molecules for in situ synthesis and biofunctionalization of gold nanoparticles for integrin-targeted cell uptake

H Unal Gulsuner, H Ceylan, MO Guler… - ACS Applied Materials …, 2015 - ACS Publications
We describe design and synthesis model of multidomain (modular) peptides (MDPs), which
direct a reaction cascade coupling the synthesis and surface functionalization of gold …

Shuttling gold nanoparticles into tumoral cells with an amphipathic proline‐rich peptide

S Pujals, NG Bastús, E Pereiro… - …, 2009 - Wiley Online Library
Golden bullets: The amphipathic proline‐rich cell‐penetrating peptide sweet arrow peptide
(SAP) is able to transport 12 nm gold nanoparticles efficiently into HeLa cells, as observed …