Tooth movements associated with orthodontic treatment often cause tooth pain. However,
the detailed mechanism remains unclear. Here, we examined the involvement of periodontal …

This study aimed to explore the role of acid-sensing ion channel 3 (ASIC3) in the modulation
of tooth mechanical hyperalgesia induced by orthodontic tooth movement. In male Sprague …

Objectives: This study aimed to clarify the roles of Acid-sensing ion channel 3 (ASIC3) in
orofacial pain following experimental tooth movement. Materials and methods: Sixty male …

Orthodontic tooth movement elicits alveolar bone remodeling and orofacial pain that is
manifested by tooth mechanical hyperalgesia. Nerve growth factor (NGF) is upregulated in …

Somatosensory information derived from the periodontal ligaments plays a critical role in
identifying the strength and direction of occlusal force. The orthodontic force needed to move …

Orthodontic tooth movement is accompanied by inflammatory responses in the periodontal
ligament. Chemical mediators such as interleukin-1β have key roles in nociception around …

Objectives Orthodontic tooth movement (OTM) increases sympathetic and sensory
neurological markers in periodontal tissue. However, the relationship between the …

Background Masticatory muscle pain may occur following immediate occlusal alteration by
dental treatment. The underlying mechanisms are poorly understood. Transient receptor …

The impairment of orofacial motor function during orthodontic treatment needs to be
addressed, because most orthodontic patients experience pain and motor excitability would …

Although orthodontic treatment is common, orthodontic force often induced pain. Low-level
laser therapy (LLLT) has been investigated to improve therapeutic comfort. In dentistry, LLLT …