RNApolII-dependent transcription is repressed in primordial germ cells of many animals
during early development and is thought to be important for maintenance of germline fate by …

Eggs of all animals contain mRNAs and proteins that are supplied to or deposited in the egg
as it develops during oogenesis. These maternal gene products regulate all aspects of …

Upon fertilization, drastic chromatin reorganization occurs during preimplantation
development. However, the global chromatin landscape and its molecular dynamics in this …

The pre-implantation period of mammalian development includes the formation of the
zygote, the activation of the embryonic genome (EGA), and the beginning of cellular …

We describe the genome-wide distributions and temporal dynamics of nucleosomes and
post-translational histone modifications throughout the maternal-to-zygotic transition in …

Early animal development is controlled by maternally encoded RNAs and proteins, which
are loaded into the egg during oogenesis. Oocyte maturation and egg activation trigger …

During embryogenesis, the genome shifts from transcriptionally quiescent to extensively
active in a process known as Zygotic Genome Activation (ZGA). In Drosophila, the pioneer …

Control of metazoan embryogenesis shifts from maternal to zygotic gene products as the
zygotic genome becomes transcriptionally activated. In Drosophila, zygotic genome …

Histone modifications are critical epigenetic indicators of chromatin state associated with
gene expression. Although the reprogramming patterns of H3K4me3 and H3K27me3 have …

The onset of metazoan development requires that two terminally differentiated germ cells, a
sperm and an oocyte, become reprogrammed to the totipotent embryo, which can …