CT is a powerful method for noninvasive assessment of the lung. Advancements to CT
technology have guided the high-resolution structural and functional assessment of lung …

Rationale: Endothelial dysfunction is of interest in relation to smoking-associated
emphysema, a component of chronic obstructive pulmonary disease (COPD). We previously …

Chronic obstructive pulmonary disease (COPD) is a debilitating lung disease almost
exclusively related to tobacco smoke. COPD symptoms are typical of numerous other …

Objective: Assess regional changes in CT-based ventilation and perfusion matching (V/Q)
after sildenafil in smokers and non-smokers. Methods: Cohort of 79 smokers and 55 non …

Objectives The objective of this study was to determine whether automated quantification of
lung perfused blood volume (PBV) in dual-energy computed tomographic pulmonary …

Recent evidence suggests that endothelial dysfunction and pathology of pulmonary vascular
responses may serve as a precursor to smoking-associated emphysema. Although it is …

Background Tobacco smoking may cause pulmonary perfusion abnormality. Assessment of
the lung perfusion characteristics is very significant to timely treatment and prevent disease …

INTRODUCTION: Studies have shown an association between pulmonary vascular
dysfunction and emphysema susceptibility. Using dynamic, contrast-enhanced multi …

Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition with variable
clinical and pathophysiologic features. Functional information of the lungs is important to …

Introduction: Vascular remodeling has been associated with the pathogenesis and
progression of interstitial lung diseases (ILD) and other pulmonary diseases such as …