Thymic-deficient hosts rely primarily on antigen-driven expansion to restore the peripheral T-
cell compartment following T-cell depletion (TCD). The degree to which this thymic …

Impaired immune reconstitution has moved to the forefront of clinical problems limiting
progress in allogeneic bone marrow transplantation (BMT). The identification of therapies …

Bone marrow transplantation (BMT) is followed by a period of profound immune deficiency,
during which new T lymphocytes are generated from either stem cells or immature thymic …

Thymic-dependent differentiation of bone marrow (BM)-derived progenitors and thymic-
independent antigen-driven peripheral expansion of mature T cells represent the 2 primary …

Abstract Interleukin (IL)-7 is known to up-regulate thymopoietic pathways of T-cell
regeneration. Recent work also has shown it to potently enhance thymic-independent …

Recent evidence has implicated interleukin-7 (IL-7) as a master regulator of T-cell
homeostasis, based upon its essential role in the homeostatic expansion of naive T-cell …

We used clinically relevant murine allogeneic bone marrow transplantation (BMT) models to
study the mechanisms by which IL-7 administration can improve posttransplant peripheral T …

Abstract Interleukin-7 (IL-7) has been shown to enhance thymic output of newly developed T
cells following bone marrow transplantation (BMT) in mice. In addition, IL-7 may affect …

Interleukin-7 (IL-7) is a homeostatic cytokine for resting T cells with increasing serum and
tissue levels during T cell depletion. In preclinical studies, IL-7 therapy exerts marked …

Interleukin (IL)-7 promotes both thymopoiesis and mature T lymphocyte survival and
proliferation in experimental murine models of hematopoietic stem cell (HSC) …