The mixed lineage leukemia (MLL) family of proteins became known initially for the
leukemia link of its founding member. Over the decades, the MLL family has been …

Several acute lymphoblastic and myelogenous leukemias are correlated with alterations in
the human mixed lineage leukemia protein‐1 (MLL1) gene. MLL1 is a member of the …

The Mixed Lineage Leukemia 2 (MLL2) protein, also known as KMT2B, belongs to the family
of mammalian histone H3 lysine 4 (H3K4) methyltransferases. It is a large protein of 2715 …

Gene expression within the context of eukaryotic chromatin is regulated by enzymes that
catalyze histone lysine methylation. Histone lysine methyltransferases that have been …

Transcription in eukaryotic genomes depends on enzymes that regulate the degree of
histone H3 lysine 4 (H3K4) methylation. The mixed lineage leukemia protein-1 (MLL1) is a …

The mixed lineage leukemia-1 (MLL1) core complex predominantly catalyzes mono-and
dimethylation of histone H3 at lysine 4 (H3K4) and is frequently altered in aggressive acute …

The mixed lineage leukemia (MLL) family of genes, also known as the lysine N-
methyltransferase 2 (KMT2) family, are homologous to the evolutionarily conserved trithorax …

The mixed-lineage leukemia (MLL1/ALL-1/HRX) histone methyltransferase is involved in the
epigenetic maintenance of transcriptional memory and the pathogenesis of human …

Accumulating recent evidence supports the notion that many enzymes that modify histones
are fundamental players in normal hematopoiesis as well as hematologic malignancies, and …

Here we report a comprehensive characterization of our recently developed inhibitor MM-
401 that targets the MLL1 H3K4 methyltransferase activity. MM-401 is able to specifically …