Role of MAPKs in development and differentiation: lessons from knockout mice
The ERK, p38MAPK, JNK mitogen-activated protein kinases (MAPKs) are intracellular
signaling pathways that play a pivotal role in many essential cellular processes such as …
signaling pathways that play a pivotal role in many essential cellular processes such as …
Diversity in function and regulation of MAP kinase pathways
KJ Blumer, GL Johnson - Trends in biochemical sciences, 1994 - cell.com
Eukaryotic cells from yeast to humans use sequential protein kinase reactions to regulate
complex cellular functions. Equivalent protein kinases in different pathways have significant …
complex cellular functions. Equivalent protein kinases in different pathways have significant …
Regulation of transcription by MAP kinase cascades
R Treisman - Current opinion in cell biology, 1996 - Elsevier
Kinases belonging to the mitogen-activated protein kinase (MAPK) family are used
throughout evolution to control the cellular responses to external signals such as growth …
throughout evolution to control the cellular responses to external signals such as growth …
Characterization of the Structure and Function of a Novel MAP Kinase Kinase (MKK6)(∗)
J Han, JD Lee, Y Jiang, Z Li, L Feng… - Journal of Biological …, 1996 - ASBMB
Mitogen-activated protein (MAP) kinases require dual phosphorylation on threonine and
tyrosine residues in order to gain enzymatic activity. This activation is carried out by a family …
tyrosine residues in order to gain enzymatic activity. This activation is carried out by a family …
The duration, magnitude and compartmentalization of ERK MAP kinase activity: mechanisms for providing signaling specificity
ERK MAP kinase signaling plays a pivotal role in diverse cellular functions, including cell
proliferation, differentiation, migration and survival. One of the central questions concerning …
proliferation, differentiation, migration and survival. One of the central questions concerning …
Deciphering the MAP kinase pathway
G L'Allemain - Progress in growth factor research, 1994 - Elsevier
MAP kinases (MAPK) are serine/threonine kinases which are activated by a dual
phosphorylation on threonine and tyrosine residues. Their specific upstream activators …
phosphorylation on threonine and tyrosine residues. Their specific upstream activators …
Mitogen-activated protein kinases in cell-cycle control
RA MacCorkle, TH Tan - Cell biochemistry and biophysics, 2005 - Springer
The mitogen-activated protein kinase (MAPK) family of kinases connects extracellular stimuli
with diverse cellular responses ranging from activation or suppression of gene expression to …
with diverse cellular responses ranging from activation or suppression of gene expression to …
ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions
Conserved signaling pathways that activate the mitogen-activated protein kinases (MAPKs)
are involved in relaying extracellular stimulations to intracellular responses. The MAPKs …
are involved in relaying extracellular stimulations to intracellular responses. The MAPKs …
Docking interactions induce exposure of activation loop in the MAP kinase ERK2
T Zhou, L Sun, J Humphreys, EJ Goldsmith - Structure, 2006 - cell.com
MAP kinases bind activating kinases, phosphatases, and substrates through docking
interactions. Here, we report a 1.9 Å crystallographic analysis of inactive ERK2 bound to a" …
interactions. Here, we report a 1.9 Å crystallographic analysis of inactive ERK2 bound to a" …
Activation of the MAP kinase homologue RK requires the phosphorylation of Thr-180 and Tyr-182 and both residues are phosphorylated in chemically stressed KB …
A MAP kinase homologue, termed the reactivating kinase (RK), lies in a signalling pathway
which mediates cellular responses to stress. Here we demonstrate that the stress-induced …
which mediates cellular responses to stress. Here we demonstrate that the stress-induced …