The novel J-domain protein Mrj1 is required for mitochondrial respiration and virulence in Cryptococcus neoformans
The opportunistic fungal pathogen Cryptococcus neoformans must adapt to the mammalian
environment to establish an infection. Proteins facilitating adaptation to novel environments …
environment to establish an infection. Proteins facilitating adaptation to novel environments …
Mitochondria in Cryptococcus: an update of mitochondrial transcriptional regulation in Cryptococcus
Y Meng, C Ding - Current genetics, 2023 - Springer
Encapsulated Cryptococcus species are responsible for approximately 15% of AIDS-related
mortality. Numerous intriguing investigations have demonstrated that mitochondria play a …
mortality. Numerous intriguing investigations have demonstrated that mitochondria play a …
Maintenance of mitochondrial morphology in Cryptococcus neoformans is critical for stress resistance and virulence
AL Chang, TL Doering - MBio, 2018 - Am Soc Microbiol
Mitochondria are essential organelles that act in pathways including ATP production, β-
oxidation, and clearance of reactive oxygen species. They occur as a complex reticular …
oxidation, and clearance of reactive oxygen species. They occur as a complex reticular …
The zinc finger protein Mig1 regulates mitochondrial function and azole drug susceptibility in the pathogenic fungus Cryptococcus neoformans
The opportunistic pathogen Cryptococcus neoformans causes fungal meningoencephalitis
in immunocompromised individuals. In previous studies, we found that the Hap complex in …
in immunocompromised individuals. In previous studies, we found that the Hap complex in …
[HTML][HTML] Dnj1 promotes virulence in Cryptococcus neoformans by maintaining robust endoplasmic reticulum homeostasis under temperature stress
The capacity of opportunistic fungal pathogens such as Cryptococcus neoformans to cause
disease is dependent on their ability to overcome an onslaught of stresses including …
disease is dependent on their ability to overcome an onslaught of stresses including …
Mitochondria and the regulation of hypervirulence in the fatal fungal outbreak on Vancouver Island
In our recent paper, we demonstrated that the hypervirulence exhibited by a lineage of the
fatal fungal pathogen Cryptococcus gattii is associated with its mitochondrial gene …
fatal fungal pathogen Cryptococcus gattii is associated with its mitochondrial gene …
A Predicted Mannoprotein Cmp1 Regulates Fungal Virulence in Cryptococcus neoformans
LT Han, L Wu, TB Liu - Pathogens, 2020 - mdpi.com
The capsule of the fungal pathogen Cryptococcus neoformans consists of
glucuronoxylomannan (GXM), glucuronoxylomannogalactan (GXMGal), and mannoproteins …
glucuronoxylomannan (GXM), glucuronoxylomannogalactan (GXMGal), and mannoproteins …
Leu1 plays a role in iron metabolism and is required for virulence in Cryptococcus neoformans
Amino acid biosynthetic pathways that are absent in mammals are considered an attractive
target for antifungal therapy. Leucine biosynthesis is one such target pathway, consisting of …
target for antifungal therapy. Leucine biosynthesis is one such target pathway, consisting of …
Connecting iron regulation and mitochondrial function in Cryptococcus neoformans
LC Horianopoulos, JW Kronstad - Current opinion in microbiology, 2019 - Elsevier
Iron acquisition is essential for the proliferation of microorganisms, and human pathogens
such as the fungus Cryptococcus neoformans must use sophisticated uptake mechanisms to …
such as the fungus Cryptococcus neoformans must use sophisticated uptake mechanisms to …
The RAM signaling pathway links morphology, thermotolerance, and CO2 tolerance in the global fungal pathogen Cryptococcus neoformans
The environmental pathogen Cryptococcus neoformans claims over 180,000 lives each
year. Survival of this basidiomycete at host CO2 concentrations has only recently been …
year. Survival of this basidiomycete at host CO2 concentrations has only recently been …