Epigenome-wide association study of fasting blood lipids in the genetics of lipid-lowering drugs and diet network study
Background—Genetic research regarding blood lipids has largely focused on DNA
sequence variation; few studies have explored epigenetic effects. Genome-wide surveys of …
sequence variation; few studies have explored epigenetic effects. Genome-wide surveys of …
Epigenome‐wide study identifies novel methylation loci associated with body mass index and waist circumference
Objective To conduct an epigenome‐wide analysis of DNA methylation and obesity traits.
Methods DNA methylation was quantified in CD4+ T‐cells using the Illumina Infinium …
Methods DNA methylation was quantified in CD4+ T‐cells using the Illumina Infinium …
A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids
Here we examine the association between DNA methylation in circulating leukocytes and
blood lipids in a multi-ethnic sample of 16,265 subjects. We identify 148, 35, and 4 novel …
blood lipids in a multi-ethnic sample of 16,265 subjects. We identify 148, 35, and 4 novel …
Epigenetic patterns in blood associated with lipid traits predict incident coronary heart disease events and are enriched for results from genome-wide association …
Background—Genome-wide association studies have identified loci influencing circulating
lipid concentrations in humans; further information on novel contributing genes, pathways …
lipid concentrations in humans; further information on novel contributing genes, pathways …
Methylation at CPT1A locus is associated with lipoprotein subfraction profiles [S]
AC Frazier-Wood, S Aslibekyan, DM Absher… - Journal of lipid …, 2014 - ASBMB
Lipoprotein subfractions help discriminate cardiometabolic disease risk. Genetic loci
validated as associating with lipoprotein measures do not account for a large proportion of …
validated as associating with lipoprotein measures do not account for a large proportion of …
Blood lipids influence DNA methylation in circulating cells
Background Cells can be primed by external stimuli to obtain a long-term epigenetic
memory. We hypothesize that long-term exposure to elevated blood lipids can prime …
memory. We hypothesize that long-term exposure to elevated blood lipids can prime …
Association of DNA Methylation at CPT1A Locus with Metabolic Syndrome in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) Study
In this study, we conducted an epigenome-wide association study of metabolic syndrome
(MetS) among 846 participants of European descent in the Genetics of Lipid Lowering Drugs …
(MetS) among 846 participants of European descent in the Genetics of Lipid Lowering Drugs …
Epigenome-wide association study (EWAS) on lipids: the Rotterdam Study
Background DNA methylation is a key epigenetic mechanism that is suggested to be
associated with blood lipid levels. We aimed to identify CpG sites at which DNA methylation …
associated with blood lipid levels. We aimed to identify CpG sites at which DNA methylation …
SNPs located at CpG sites modulate genome-epigenome interaction
D Zhi, S Aslibekyan, MR Irvin, SA Claas, IB Borecki… - Epigenetics, 2013 - Taylor & Francis
DNA methylation is an important molecular-level phenotype that links genotypes and
complex disease traits. Previous studies have found local correlation between genetic …
complex disease traits. Previous studies have found local correlation between genetic …
Epigenome-wide association study of fasting measures of glucose, insulin, and HOMA-IR in the Genetics of Lipid Lowering Drugs and Diet Network study
Known genetic susceptibility loci for type 2 diabetes (T2D) explain only a small proportion of
heritable T2D risk. We hypothesize that DNA methylation patterns may contribute to variation …
heritable T2D risk. We hypothesize that DNA methylation patterns may contribute to variation …