Increased osteopontin levels in the cerebrospinal fluid of patients with multiple sclerosis
M Braitch, R Nunan, G Niepel, LJ Edwards… - Archives of …, 2008 - jamanetwork.com
Objective To determine cerebrospinal fluid levels of osteopontin (OPN), a proinflammatory
cytokine that was found to be overexpressed in multiple sclerosis lesions and increased in …
cytokine that was found to be overexpressed in multiple sclerosis lesions and increased in …
Increased osteopontin plasma levels in multiple sclerosis patients correlate with bone-specific markers
MHJ Vogt, J ten Kate, RJM Drent… - Multiple Sclerosis …, 2010 - journals.sagepub.com
The pro-inflammatory cytokine osteopontin has been found to be highly expressed in
multiple sclerosis lesions and plasma levels are increased during relapses in relapse-onset …
multiple sclerosis lesions and plasma levels are increased during relapses in relapse-onset …
Osteopontin concentrations are increased in cerebrospinal fluid during attacks of multiple sclerosis
L Börnsen, M Khademi, T Olsson… - Multiple Sclerosis …, 2011 - journals.sagepub.com
Background: The cytokine osteopontin (OPN) is a potential key player in the
immunopathogenesis of multiple sclerosis (MS) and a candidate biomarker for disease …
immunopathogenesis of multiple sclerosis (MS) and a candidate biomarker for disease …
Osteopontin Is Associated with Multiple Sclerosis Relapses
M Stampanoni Bassi, F Buttari, L Gilio, E Iezzi, G Galifi… - Biomedicines, 2023 - mdpi.com
Background: Osteopontin, an extracellular matrix protein involved in bone remodeling,
tissue repair and inflammation, has previously been associated with increased inflammation …
tissue repair and inflammation, has previously been associated with increased inflammation …
Elevated osteopontin levels in active relapsing‐remitting multiple sclerosis
MHJ Vogt, L Lopatinskaya, M Smits… - Annals of …, 2003 - Wiley Online Library
In the search for proteins that might play a role in the pathogenesis of multiple sclerosis
(MS), osteopontin (OPN) has been identified as the most prominent cytokine‐encoding gene …
(MS), osteopontin (OPN) has been identified as the most prominent cytokine‐encoding gene …
Specificity and correlation with disease activity of cerebrospinal fluid osteopontin levels in patients with multiple sclerosis
SA Chowdhury, J Lin, SA Sadiq - Archives of neurology, 2008 - jamanetwork.com
Background Despite recent advances in therapy that have improved the overall disease
course in multiple sclerosis (MS), the prognosis at the outset remains unpredictable …
course in multiple sclerosis (MS), the prognosis at the outset remains unpredictable …
Plasma osteopontin levels in multiple sclerosis
M Comabella, I Pericot, R Goertsches, C Nos… - Journal of …, 2005 - Elsevier
Osteopontin (OPN) is a pleiotropic integrin binding protein with functions in cell-mediated
immunity, inflammation, tissue repair, and cell survival. Recent studies have shown that OPN …
immunity, inflammation, tissue repair, and cell survival. Recent studies have shown that OPN …
Evaluation of circulating osteopontin levels in an unselected cohort of patients with multiple sclerosis: relevance for biomarker development
P Kivisäkk, BC Healy, K Francois… - Multiple Sclerosis …, 2014 - journals.sagepub.com
Background: Osteopontin (OPN) is a pleiotropic protein with important roles in inflammation
and immunity that has been suggested as a candidate biomarker for disease activity in …
and immunity that has been suggested as a candidate biomarker for disease activity in …
The role of osteopontin: a shared pathway in the pathogenesis of multiple sclerosis and osteoporosis?
A Altıntaş, G Saruhan-Direskeneli, G Benbir… - Journal of the …, 2009 - Elsevier
Osteopontin (OPN) was suggested to have a role in the pathophysiology of MS and in bone
metabolism. However, we formerly reported increased presence of osteoporosis in MS …
metabolism. However, we formerly reported increased presence of osteoporosis in MS …
Plasma osteopontin levels are associated with disease activity in the patients with multiple sclerosis and neuromyelitis optica
Y Shimizu, K Ota, R Ikeguchi, S Kubo… - Journal of …, 2013 - Elsevier
Osteopontin (OPN) up-regulates pro-inflammatory cytokines from both T helper type 1 and T
helper type 17 cell pathways. We measured plasma OPN levels in Japanese multiple …
helper type 17 cell pathways. We measured plasma OPN levels in Japanese multiple …