Superoxide dismutases and their impact upon human health

F Johnson, C Giulivi - Molecular aspects of medicine, 2005 - Elsevier
Superoxide dismutases (SOD), a group of metal-containing enzymes, have a vital anti-
oxidant role in human health, conferred by their scavenging of one of the reactive oxygen …

Superoxide dismutases (SODs) and SOD mimetics

GEO Borgstahl, RE Oberley-Deegan - Antioxidants, 2018 - mdpi.com
Superoxide dismutase (SOD) is the only known enzyme to directly scavenge a free radical.
Specifically, SOD dismutes superoxide to oxygen and hydrogen peroxide with high …

Superoxide dismutases: role in redox signaling, vascular function, and diseases

T Fukai, M Ushio-Fukai - Antioxidants & redox signaling, 2011 - liebertpub.com
Excessive reactive oxygen species Revised abstract, especially superoxide anion (O2•−),
play important roles in the pathogenesis of many cardiovascular diseases, including …

SOD, oxidative stress and human pathologies: a brief history and a future vision

JM McCord, MA Edeas - Biomedicine & Pharmacotherapy, 2005 - Elsevier
Superoxide dismutase (SOD) has now been known for 35 years. While the superoxide
radical and SOD have been implicated in many disease states including inflammatory …

A review of the catalytic mechanism of human manganese superoxide dismutase

J Azadmanesh, GEO Borgstahl - Antioxidants, 2018 - mdpi.com
Superoxide dismutases (SODs) are necessary antioxidant enzymes that protect cells from
reactive oxygen species (ROS). Decreased levels of SODs or mutations that affect their …

Superoxide dismutase--applications and relevance to human diseases.

R Noor, S Mittal, J Iqbal - Medical science monitor: international …, 2002 - europepmc.org
Reactive oxygen species, such as superoxide radicals, are thought to underlie the
pathogenesis of various diseases. Almost 3 to 10% of the oxygen utilized by tissues is …

Expanding roles of superoxide dismutases in cell regulation and cancer

M Che, R Wang, X Li, HY Wang, XFS Zheng - Drug discovery today, 2016 - Elsevier
Highlights•Superoxide dismutases (SODs) have important regulatory functions in
metabolism, signalling and transcription.•SODs are crucial for cancer cell growth …

Regulation of superoxide dismutase genes: implications in disease

L Miao, DKS Clair - Free Radical Biology and Medicine, 2009 - Elsevier
Numerous short-lived and highly reactive oxygen species (ROS) such as superoxide (O2−),
hydroxyl radical, and hydrogen peroxide are continuously generated in vivo. Depending …

Superoxide dismutase 1 in health and disease: how a frontline antioxidant becomes neurotoxic

BG Trist, JB Hilton, DJ Hare, PJ Crouch… - Angewandte Chemie …, 2021 - Wiley Online Library
Cu/Zn superoxide dismutase (SOD1) is a frontline antioxidant enzyme catalysing superoxide
breakdown and is important for most forms of eukaryotic life. The evolution of aerobic …

The basic and applied aspects of superoxide dismutase

A Bafana, S Dutt, A Kumar, S Kumar… - Journal of Molecular …, 2011 - Elsevier
Superoxide dismutase (SOD) is among the most potent antioxidants known in nature and is
an important constituent of cellular defence against oxidative stress. The enzyme shows …